Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: A nested case-control study
Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: A nested case-control study
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DOI：
10.1373/clinchem.2006.074476
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发表时间：
2006-11-01
影响因子：
9.3
通讯作者：
Zee, Robert Y. L.
中科院分区：
文献类型：
--
作者：
Hegener, Hillary H.;Lee, I-Min;Zee, Robert Y. L.
背景：脂联素（ADIPOQ）基因变异与糖尿病患者心血管疾病的风险相关。然而，没有关于ADIPOQ变异但无糖尿病的患者发生动脉粥样硬化血栓形成疾病风险的前瞻性数据。方法：从一组在基线时收集的DNA样本中，我们评估了14916名最初健康的美国男性的5种ADIPOQ遗传变异的存在，（rs 266729、rs 182052、rs 822396、rs 2241766和rs 1501299），（突发心肌梗死或缺血性卒中）和600名年龄和吸烟匹配的白人男性，这些男性在随访期间没有报告血管疾病结果：供试变异的基因型分布符合Hardy-Weinberg平衡。逐个标记的条件Logistic回归分析，调整潜在的危险因素，显示rs 266729 [隐性：比值比（OR），0.26; 95%置信区间（0），0.10-0.64; P = 0.004]和rs 182052 [隐性：比值比（OR），0.26; 95%置信区间（0），0.10-0.64; P = 0.004]与（隐性：OR，0.40; 95% CI，0.21-0.76; P = 0.006），缺血性卒中风险降低。这些发现在Bonferroni校正后仍然显著。基于单倍型（由rs 266729、rs 182052和rs 822396组成）的条件Logistic回归分析，调整相同的潜在危险因素，显示单倍型G-A-G（OR，0.28; 95%CI，0.09-0.87; P = 0.03）与缺血性卒中风险降低相关。预先指定的分析仅限于参与者没有基线糖尿病表现出类似的显着findings.Conclusions：目前的前瞻性研究提供了进一步的证据，脂联素基因变异的保护作用，缺血性中风的风险是独立的糖尿病的存在。(c)2006年美国临床化学协会。
Background: Adiponectin (ADIPOQ) gene variations are associated with risk of cardiovascular disease in patients with diabetes. No prospective data are available, however, on the risk of atherothrombotic disorders in persons with ADIPOQ variations who do not have diabetes.Methods: From a group of DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we assessed the presence of 5 ADIPOQ genetic variants (rs266729, rs182052, rs822396, rs2241766, and rs1501299) in samples from 600 Caucasian men who subsequently suffered an atherothrombotic event (incident myocardial infarction or ischemic stroke) and from 600 age- and smoking-matched Caucasian men who remained free of reported vascular disease during follow-up (controls).Results: Genotype distributions for the variations tested were in Hardy-Weinberg equilibrium. Marker-by-marker conditional logistic regression analysis, adjusted for potential risk factors, showed an association of rs266729 [recessive: odds ratio (OR), 0.26; 95% confidence interval (0), 0.10-0.64; P = 0.004] and rs182052 (recessive: OR, 0.40; 95% Cl, 0.21-0.76; P = 0.006) with decreased risk of ischemic stroke. These findings remained significant after Bonferroni correction. Haplotype-based (constituted by rs266729, rs182052, and rs822396) conditional logistic regression analysis, adjusted for the same potential risk factors, showed an association of haplotype G-A-G (OR, 0.28; 95% Cl, 0.09-0.87; P = 0.03) with decreased risk of ischemic stroke. Prespecified analysis limited to participants without baseline diabetes showed similar significant findings.Conclusions: The present prospective investigation provides further evidence for a protective role of adiponectin gene variation in the risk of ischemic stroke that was independent of the presence of diabetes. (c) 2006 American Association for Clinical Chemistry.