Association between Inhaled Corticosteroids and Expiratory Central Airway Collapse in Smokers.
Association between Inhaled Corticosteroids and Expiratory Central Airway Collapse in Smokers.
复制标题
吸烟者吸入皮质类固醇与呼气中央气道塌陷之间的关联。
DOI：
10.1164/rccm.202008-3122le
复制
发表时间：
2021
影响因子：
24.7
通讯作者：
Bhatt,SuryaP
中科院分区：
文献类型：
--
作者：
Hudali,TamerH;Bodduluri,Sandeep;Dransfield,MarkT;Bhatt,SuryaP
我们分析了COPD基因（COPD遗传流行病学）队列参与者的数据;该研究的详细信息已在之前发表（8）。简而言之，该队列包括患有和不患有COPD的当前和既往吸烟者。受试者根据美国胸科学会指南进行肺量测定（9）。在完全吸气和呼气末采集计算机断层扫描（CT）。ECAC的存在定义为气管和/或中间支气管横截面积减少≥ 50%（4）。根据受试者的报告，在入组时获得长效β受体激动剂（LABA）、长效抗毒蕈碱药（LAMA）和ICS的使用数据，并在可用时检查其药物。
MethodsWe analyzed data from participants enrolled in the COPDGene (Genetic Epidemiology of COPD) cohort; the details of the study have been published previously (8). Briefly, the cohort included current and former smokers with and without COPD. Subjects underwent spirometry according to the American Thoracic Society guidelines (9). Computed tomography (CT) scans were acquired at full inspiration and end exhalation. The presence of ECAC was defined by a≥ 50% reduction of the cross-sectional area of the trachea and/or bronchus intermedius (4). Data on use of long-acting β-agonists (LABAs), long-acting antimuscarinics (LAMAs), and ICSs were obtained at enrollment as reported by participants and, when available, by inspecting their medications.