Metabolic and haemodynamic effects of dopamine plus domperidone in volunteers
Metabolic and haemodynamic effects of dopamine plus domperidone in volunteers
复制标题
多巴胺加多潘立酮对志愿者的代谢和血液动力学影响
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
M. Georgieff
中科院分区：
文献类型：
--
作者：
H. Ensinger;K. Lindner;A. Goertz;A. Grünert;F. Ahnefeld;M. Georgieff
多巴胺输注速率与动、静脉多巴胺血浆浓度的关系及其对血流动力学和代谢的影响尚未见研究。7名志愿者以5种输注速率（1、3、6、9、13 μg/kg / min）逐步递增，每步持续30分钟。由于多巴胺可引起恶心和呕吐，在多潘立酮输注速度超过3μg/kg /分钟后，研究了这种关系。采用二维超声心动图评估血流动力学影响。在最高输注速率下，动脉血浆多巴胺浓度达到1379±181 nmol/l。多巴胺输注率与动脉、静脉血浆浓度均呈线性相关。心率和舒张压没有明显变化。收缩压、射血分数和心脏指数呈剂量依赖性增加。在两次低剂量多巴胺输注期间，全身血管阻力下降，与三次高输注速率期间的基线值没有差异。在13 μg/kg / min的输注速率下，血浆葡萄糖和非酯化脂肪酸浓度分别从5.3±0.4 μmol/l和360±119 μmol/l增加到971±307 μmol/l。血浆去甲肾上腺素浓度随多巴胺血药浓度升高至7.84±2.46 nmol/l，多巴胺血药浓度的作用可能与一种间接的拟交感神经效应有关。
There are no studies of the relationship between infusion rate of dopamine and the arterial and venous dopamine plasma concentration and the resulting haemodynamic and metabolic effects. Dopamine was administered to seven volunteers using five infusion rates (1, 3, 6, 9, 13 μg/kg per minute) in an escalating sequence lasting for 30 min for each step. Since dopamine can cause nausea and vomiting, this relationship was investigated after administration of domperidone for infusion rates above 3μg/kg per minute. Haemodynamic effects were assessed using 2-dimensional echocardiography. During the highest infusion rate the arterial plasma dopamine concentration reached 1,379±181 nmol/l. There was a linear correlation between the dopamine infusion rate and both the arterial and the venous plasma concentration. There was no significant change in heart rate or diastolic blood pressure. Systolic blood pressure, ejection fraction and cardiac index increased in a dose-dependent manner. Systemic vascular resistance decreased during the two low doses of dopamine and was not different from baseline values during the three high infusion rates. The plasma concentrations of glucose and non-esterified fatty acids increased from 5.3±0.4 to 6.8±0.9 nmol/l, and from 360±119 to 971±307 μmol/l, respectively, during the 13 μg/kg per minute infusion rate. As the plasma noradrenaline concentration increased up to 7.84±2.46 nmol/l in correlation to the dopamine plasma concentration, an indirect sympathomimetic effect may contribute to the actions of dopamine plasma concentration.
比较收缩末压-时长关系和预负荷可复张卒中做功作为清醒和麻醉、长期使用仪器的狗的心肌收缩力指标。
影响因子：
8.8
作者：
Pagel,PS;Kampine,JP;Schmeling,WT;Warltier,DC
通讯作者：
Warltier,DC