Gastric adenocarcinoma in young patients: a population-based appraisal.
Gastric adenocarcinoma in young patients: a population-based appraisal.
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DOI：
10.1245/s10434-011-1647-x
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发表时间：
2011-10
影响因子：
3.7
通讯作者：
Chang GJ
中科院分区：
文献类型：
--
作者：
Al-Refaie WB;Hu CY;Pisters PW;Chang GJ
尽管国际上对年轻胃癌患者的研究主要报告了与老年患者相比有利的生存结局，但美国的经验显示了更广泛的结局。我们研究了年轻（45岁以下）对胃腺癌的表现和生存结果的影响。在1988-2006年的监测流行病学和最终结果（SEER）登记中，共确定了33，236例胃腺癌患者。使用广义线性模型对相对生存期进行多变量回归分析，以校正协变量效应。年轻患者比老年患者更有可能在就诊时有晚期淋巴结和远处转移性疾病（两者p < 0.001）。未校正的相对生存分析表明，与中年和老年患者相比，年轻患者具有良好的分期分层生存。这些结果在调整协变量后仍然存在。在对接受癌症定向手术进行分层后，年龄越小，分期分层的相对生存率越高。这是美国最大的基于人群的年龄相关胃癌结局研究。虽然年轻胃癌患者的病情更严重，但他们的校正分期分层相对生存率比老年患者更有利。这项研究支持在年轻人群中采用阶段依赖性治疗方法。
Although international studies of young gastric cancer patients have mainly reported favorable survival outcomes compared to older patients, US-based experiences showed a wider spectrum of outcomes. We examined the impact of young age (under 45 years) on the presentation and survival outcomes of gastric adenocarcinoma. A total of 33,236 patients with gastric adenocarcinoma were identified within the 1988-2006 Surveillance Epidemiology and End Results (SEER) registry. Multivariate regression analysis of relative survival was performed to adjust for covariate effects using generalized linear models. Young patients were more likely than older patients to have advanced nodal and distant metastatic disease at presentation (p < 0.001 for both). Unadjusted relative survival analysis demonstrated younger patients to have favorable stage-stratified survival when compared to middle-aged and older patients. These findings persisted after adjusting for covariates. After stratifying for receipt of cancer directed surgery, younger age was associated with more favorable stage-stratified relative survival. This is the largest US population-based study of age-related gastric cancer outcomes. Although young patients with gastric cancer present with more advanced disease, their adjusted stage-stratified relative survival is more favorable than that of older patients. This study supports a stage-dependent treatment approach in younger populations.
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影响因子：
--
作者：
Smith, Brian R.;Stabile, Bruce E.
通讯作者：
Stabile, Bruce E.
影响因子：
2.3
作者：
Kim, DY;Ryu, SY;Kim, SK
通讯作者：
Kim, SK
影响因子：
3
作者：
Theuer, CP;deVirgilio, C;Stabile, BE
通讯作者：
Stabile, BE
影响因子：
3.2
作者：
Ramos-De la Medina, A;Salgado-Nesme, N;Medina-Franco, H
通讯作者：
Medina-Franco, H
影响因子：
2.5
作者：
Park, Jun Chul;Lee, Yong Chan;Kim, Choong Bai
通讯作者：
Kim, Choong Bai