Chinese ischemic stroke subclassification.
Chinese ischemic stroke subclassification.
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DOI：
10.3389/fneur.2011.00006
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发表时间：
2011
影响因子：
3.4
通讯作者：
Wang DZ
中科院分区：
文献类型：
--
作者：
Gao S;Wang YJ;Xu AD;Li YS;Wang DZ
脑卒中的准确分类对患者的护理和脑卒中临床试验的开展具有重要意义。诸如吐司、SSS-吐司、韩国吐司和A-S-C-O的当前系统具有局限性。随着新的成像技术的出现，需要有一个更准确的中风亚分类系统。中国缺血性脑卒中亚分类系统（CISS）是一个新的两步分类系统，旨在研究脑卒中的病因和潜在机制。第一步将卒中分为五类：大动脉粥样硬化（LAA），包括主动脉弓和颅内/颅外大动脉的动脉粥样硬化，心源性卒中，穿通动脉疾病，其他病因和未确定的病因。第二步是将颅内和颅外LAA缺血性卒中的潜在机制进一步分类为载瘤动脉（斑块或血栓形成）闭塞穿通动脉、动脉间栓塞、灌注不足/栓子清除受损和多种机制。虽然CISS的临床验证正在计划中，但CISS是一种创新系统，可提供有关卒中病理生理学的更详细信息。
Accurate classification of stroke has significant impact on patient care and conduction of stroke clinical trials. The current systems such as TOAST, SSS-TOAST, Korean TOAST, and A–S–C–O have limitations. With the advent of new imaging technology, there is a need to have a more accurate stroke subclassification system. Chinese ischemic stroke subclassification (CISS) system is a new two step system aims at the etiology and then underlying mechanism of a stroke. The first step classify stroke into five categories: large artery atherosclerosis (LAA), including atherosclerosis of aortic arch and intra-/extracranial large arteries, cardiogenic stroke, penetrating artery disease, other etiology, and undetermined etiology. The second step is to further classify the underlying mechanism of ischemic stroke from the intracranial and extracranial LAA into the parent artery (plaque or thrombosis) occluding penetrating artery, artery-to-artery embolism, hypoperfusion/impaired emboli clearance, and multiple mechanisms. Although clinical validation of CISS is being planned, CISS is an innovative system that offers much more detailed information on the pathophysiology of a stroke.