A Proof of Concept for Computational Fluid Dynamic Analysis of the Left Atrium in Atrial Fibrillation on a Patient-Specific Basis
A Proof of Concept for Computational Fluid Dynamic Analysis of the Left Atrium in Atrial Fibrillation on a Patient-Specific Basis
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DOI：
10.1115/1.4044583
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发表时间：
2020-01-01
影响因子：
1.7
通讯作者：
Corsi, Cristiana
中科院分区：
文献类型：
--
作者：
Masci, Alessandro;Alessandrini, Martino;Corsi, Cristiana
房颤（AF）与脑血管事件风险增加5倍相关，占所有卒中的15-18%。由AF引起的左心房（LA）的形态和功能重构有利于血液淤滞，从而增加卒中风险。在这种情况下，几项临床研究表明，可以通过使用LA和左心耳（LAA）的血流动力学信息来改善卒中风险分层。本研究的目的是开发一种个性化的左心房计算流体动力学（CFD）模型，该模型可以根据患者的具体情况阐明房颤的血流动力学影响。在本文中，我们提出了开发的模型及其应用于两个AF患者作为一个初步的进展，朝着优化中风风险分层管道。
Atrial fibrillation (AF) is associated with a fivefold increase in the risk of cerebrovascular events, being responsible of 15-18% of all strokes. The morphological and functional remodeling of the left atrium (LA) caused by AF favors blood stasis and, consequently, stroke risk. In this context, several clinical studies suggest that the stroke risk stratification could be improved by using hemodynamic information on the LA and the left atrial appendage (LAA). The goal of this study was to develop a personalized computational fluid dynamics (CFD) model of the LA which could clarify the hemodynamic implications of AF on a patient-specific basis. In this paper, we present the developed model and its application to two AF patients as a preliminary advancement toward an optimized stroke risk stratification pipeline.