Modulation of food intake by the κ opioid U-50,488H:: evidence for an effect on satiation
Modulation of food intake by the κ opioid U-50,488H:: evidence for an effect on satiation
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DOI：
10.1016/s0166-4328(00)00325-9
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发表时间：
2001-01-29
影响因子：
2.7
通讯作者：
Stewart, J
中科院分区：
文献类型：
--
作者：
Badiani, A;Rajabi, H;Stewart, J
本研究的主要目的是验证一种假说，即Kappa阿片激动剂U-50,488H(U50)的吞噬作用主要是由于对饱足感的影响。试验一，U50(2.0 mg/kg和4.0 mg/kg)的饲喂效果。I.P.)在随意接触研磨食物和三种蔗糖溶液(1、4和20%)的动物身上进行了测试。在实验2中，采用经典的“一瓶法”测试U50(4.0 mg/kg，ip)的作用。在30分钟内摄入5种不同的蔗糖溶液(1、4、16、32和40%)。终于来了。在实验3中，我们评价了U50(2.0、4.0和6.0 mg/kg)对小鼠的影响。伏隔核胞外多巴胺(DA)浓度的变化。在实验1中，U50增加了绞碎食物的摄入量，但不增加蔗糖的摄入量。在实验2中，U50增加了高浓度蔗糖溶液的摄入量，而降低了低浓度蔗糖溶液的摄入量。在实验3中，在没有食物的情况下，U50引起DA浓度的剂量依赖性降低，但在食物存在的情况下没有。对目前结果最有可能的解释是，U50通过激活阻止饱腹感和饱腹感的机制来增强摄食。相比之下，我们几乎没有发现U50对适口性有影响的证据。(C)2001 Elsevier Science B.V.保留所有权利。
The main goal of the present study was to test the hypothesis that the phophagic effect of the kappa opioid agonist U-50,488H (U50) is primarily due to an effect on satiation. In Experiment 1, the feeding effects of U50 (2.0 and 4.0 mg/kg. i.p.) was tested in animals with ad libitum access to ground food and to three sucrose solutions (1, 4, and 20%). In Experiment 2, a classical 'one-bottle' test was utilized to test for the effect of U50 (4.0 mg/kg, i.p.) on the intake of five different sucrose solutions (1, 4, 16, 32, and 40%) over a 30-min period. Finally. in Experiment 3 we evaluated the effect of U50 (2.0, 4.0, and 6.0 mg/kg, i.p.) on extracellular dopamine (DA) concentration in the nucleus accumbens. In Experiment 1. U50 enhanced the intake of ground food but not of sucrose. In Experiment 2, U50 increased the intake of high concentration sucrose solutions whereas it decreased that of low concentration solutions. In Experiment 3, U50 produced a dose-dependent decrease in DA concentrations in the absence but not in the presence of food. The most likely explanation for the present results is that U50 enhances feeding by activating mechanisms that block satiety and satiation. In contrast, we found little evidence for an effect of U50 on palatability. (C) 2001 Elsevier Science B.V. All rights reserved.