Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells.
Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells.
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DOI：
10.1016/j.molimm.2015.09.017
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发表时间：
2015-12
影响因子：
3.6
通讯作者：
Sen JM
中科院分区：
文献类型：
--
作者：
Berga-Bolaños R;Zhu WS;Steinke FC;Xue HH;Sen JM
自然杀伤T（NKT）细胞由常见的CD4+ CD8+胸腺细胞前体发育而来。在胸腺发育中调节NKT细胞发育的转录程序仍有待充分阐明。在这里，我们证明了一个细胞的内在需求的转录因子TCF 1和LEF 1的所有NKT细胞亚群的发展。TCF 1单独的条件性缺失导致NKT细胞的显著减少。当TCF 1和LEF 1都缺失时，剩余的NKT细胞被消除。这些数据揭示了TCF 1和LEF 1在NKT细胞发育中的重要作用。
Natural killer T (NKT) cells develop from common CD4+ CD8+ thymocyte precursors. Transcriptional programs that regulate the development of NKT cells in the thymus development remain to be fully delineated. Here we demonstrate a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of NKT cells. Conditional deletion of TCF1 alone results in a substantial reduction in NKT cells. The remaining NKT cells are eliminated when TCF1 and LEF1 are both deleted. These data reveal an essential role for TCF1 and LEF1 in development of NKT cells.