The telomere-associated DNA from human chromosome 20p contains a pseudotelomere structure and shares sequences with the subtelomeric regions of 4q and 18p
The telomere-associated DNA from human chromosome 20p contains a pseudotelomere structure and shares sequences with the subtelomeric regions of 4q and 18p
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DOI：
10.1006/geno.1997.5007
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发表时间：
1997-11-15
期刊：
影响因子：
4.4
通讯作者：
Dobson, MJ
中科院分区：
文献类型：
--
作者：
Chute, I;Le, YZ;Dobson, MJ
人类染色体20 p端粒已被克隆到酵母人工染色体（YAC）上。端粒相关DNA在距离染色体末端60 kb处含有一个由（TTAGGG）（n）端粒重复序列组成的间质区。由于内部端粒阵列分解成端粒，观察到YAC克隆的频繁截短。20 p内部端粒重复序列区在其着丝粒侧的侧翼是端粒相关重复序列，所述端粒相关重复序列先前已被发现邻近末端端粒重复序列阵列。20 p亚端粒区的假端粒结构类似于一些酵母亚端粒区的结构，其中这些序列充当已丢失其末端端粒重复序列阵列的染色体末端的重组修复的底物，在20 p上的内部（TTAGGG）（n）重复阵列的端粒末端侧翼序列被发现与4q，18 p和未知的其他三个亚端粒（TTAGGG）（n）区相邻。染色体末端。这些共享序列提供了人类非同源染色体之间交换的证据，（C）1997年学术出版社。
The human chromosome 20p telomere has been cloned on a yeast artificial chromosome (YAC). The telomere-associated DNA contains an interstitial tract of (TTAGGG)(n) telomeric repeats 60 kb in from the chromosome end. Frequent truncation of the YAC clone was observed due to resolution of the internal telomeric array into a telomere. The 20p internal telomeric repeat tract is flanked on its centromeric side by telomere-associated repeated sequences that have previously been found adjacent to terminal telomeric repeat arrays, The pseudotelomere structure of the 20p subtelomeric region is similar to the structure of some yeast subtelomeric regions where these sequences act as substrates for recombinational repair of chromosome ends that have lost their terminal telomeric repeat arrays, Sequences flanking the telomeric end of the internal (TTAGGG)(n) repeat array on 20p are found adjacent to three other subtelomeric (TTAGGG)(n) tracts on 4q, 18p, and an unknown. chromosome end, respectively. These shared sequences provide evidence of exchange between nonhomologous chromosomes in humans, (C) 1997 Academic Press.