Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.
Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.
复制标题
从海鞘外衣中提取的硫酸软骨素通过阻断小鼠皮肤中 NF-kappaB 的激活来抑制佛波酯诱导的炎症因子 VCAM-1 和 COX-2 的表达。
DOI：
10.1021/jf801578x
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发表时间：
2008
影响因子：
6.1
通讯作者：
Cho,Myung-Haing
中科院分区：
文献类型：
--
作者：
Xu,Cheng-Xiong;Jin,Hua;Chung,Youn-Sun;Shin,Ji-Young;Lee,Kee-Ho;BeckJr,GeorgeR;Palmos,GraceN;Choi,Byeong-Dae;Cho,Myung-Haing
Inflammatory factors are known to play a key role in promoting tumorigenesis; therefore, it is a promising strategy to inhibit the inflammation for cancer prevention. The current study was performed to investigate the potential effects of chondroitin sulfate (CS) extracted from ascidian tunic on the expression of inflammatory factors induced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) and to elucidate the underlying molecular mechanism of CS action in mouse skin inflammation. TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin. These studies suggest that CS from ascidian tunic may be developed as an effective natural anti-inflammatory agent.
