Welsh onion (Allium fistulosum L) extracts Alter vascular responses in rat aortae
Welsh onion (Allium fistulosum L) extracts Alter vascular responses in rat aortae
复制标题
DOI：
10.1097/00005344-199904000-00001
复制
发表时间：
1999-04-01
影响因子：
3
通讯作者：
Chen, HI
中科院分区：
文献类型：
--
作者：
Chen, JH;Tsai, SJ;Chen, HI
大葱是葱属植物的一员，被用于预防心血管疾病。然而，其潜在的机制仍不清楚。我们研究了大葱提取物（绿色或白色部分，生的或煮的）是否可以改变体外血管反应在Sprague-Dawley大鼠的胸腰椎。通过应用各种抑制剂，如N-ω-硝基-L-精氨酸（10（-4）M）、四乙基铵（10（-3）M）和SQ 29548（10（-5）M），检查内皮衍生因子在大葱提取物诱导的血管反应中的可能作用。我们的研究结果表明，大葱提取物引起血管舒张预收缩血管环。这些影响在用生绿叶提取物（RG）处理的血管环中最为明显。低剂量RG诱导血管舒张，这是由内皮源性一氧化氮介导的。高剂量RG诱导内皮非依赖性血管舒张。另一方面，煮沸的大葱提取物也刺激了内皮源性收缩因子的释放，这可能是血栓素A（2）。我们的结论是，大葱提取物可以调节血管紧张度在内皮依赖和内皮非依赖的方式。
Welsh onion, a member of the genus Allium, has been consumed for prevention of cardiovascular disorders. However, its underlying mechanisms are still unclear. We investigated whether Welsh onion extracts (green or white portion, raw or boiled) can alter vascular responses in vitro in the thoracic aortae of Sprague-Dawley rats. The possible roles of endothelium-derived factors in the Welsh onion extract-induced vascular responses were examined by applying various inhibitors, such as N-omega-nitro-L-arginine (10(-4) M), tetraethylammonium (10(-3) M), and SQ29548 (10(-5) M). Our results showed that Welsh onion extracts caused vasodilation on precontracted vessel rings. These effects were most pronounced in vessel rings treated with raw green-leaf extract (RG). Low doses of RG induced vasorelaxation, which was mediated by endothelium-derived nitric oxide. High doses of RG induced endothelium-independent vasorelaxation. On the other hand, the boiled Welsh onion extract also stimulated the release of an endothelium-derived contracting factor, which might be thromboxane A(2). We conclude that Welsh onion extract can modulate vascular tone in both endothelium-dependent and endothelium-independent manners.