Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl Cyclase.
Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl Cyclase.
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原卟啉 IX/Cobyrinate 衍生杂种 - 可溶性鸟苷酸环化酶的新型激活剂。
DOI：
10.1002/ejoc.201201303
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发表时间：
2013
影响因子：
2.8
通讯作者：
Gryko,Dorota
中科院分区：
文献类型：
--
作者：
Chromiński,Mikołaj;Proinsias,KeithÓ;Martin,Emil;Gryko,Dorota
通过应用 CuOAc 催化的叠氮-炔环加成 (CuAAC)“点击”反应制备钴酸/原卟啉 IX 分子杂化物。该合成涉及选择性制备分别具有末端炔烃和叠氮部分的钴酸和 PpIX 衍生结构单元，然后进行 CuOAc 催化的环加成反应。合成的分子激活可溶性鸟苷酸环化酶，并表现出强烈的接头长度/激活依赖性。
Cobyrinate/protoporphyrin IX molecular hybrids were prepared through application of the CuOAc catalyzed azide‐alkyne cycloaddition (CuAAC) "click" reaction. The synthesis involved selective preparation of cobyrinate and PpIX derived building blocks possessing respectively terminal alkyne and azide moieties, followed by a CuOAc catalyzed cycloaddition reaction. Synthesized molecules activated soluble guanylyl cyclase and showed strong linker‐length/activation dependence.