Preparation and characterization of alginate-N-2-hydroxypropyl trimethyl ammonium chloride chitosan microcapsules loaded with patchouli oil
Preparation and characterization of alginate-N-2-hydroxypropyl trimethyl ammonium chloride chitosan microcapsules loaded with patchouli oil
复制标题
海藻酸盐-N-2-羟丙基三甲基氯化铵壳聚糖广藿香油微胶囊的制备及表征
DOI：
10.1039/c4ra14844d
复制
发表时间：
2015-01-01
期刊：
影响因子：
3.9
通讯作者：
Wu, Hong
中科院分区：
文献类型：
--
作者：
Chen, Minjie;Liu, Jiayi;Wu, Hong
采用复凝聚法制备了含有广藿香油的海藻酸钠（Alg）-N-2-羟丙基三甲基氯化铵壳聚糖（HACC）微胶囊。考察了乳化工艺中表面活性剂用量和搅拌速度对粒径分布的影响。扫描电子显微镜（SEM）显示微胶囊为规则球形，粒径为0.5~5 μ m。不同芯壁比的微胶囊的释放均表现出先快速释放后缓慢释放的过程，符合Rigter-Peppas释放动力学规律。采用纸片扩散法和最小抑菌浓度法对微胶囊的抑菌活性进行了评价，结果表明，载药微胶囊对大肠杆菌和金黄色葡萄球菌的抑菌效果优于空心微胶囊。该微胶囊可作为药物释放系统应用于医学中，作为抗菌剂应用于纺织工业中，以及作为固定剂应用于香料工业中。
In this work, alginate (Alg)-N-2-hydroxypropyl trimethyl ammonium chloride chitosan (HACC) microcapsules containing patchouli oil were prepared by a complex coacervation method. The effects of the emulsification process including amount of surfactants and stirring rate on the particle size distributions were investigated. Scanning electron microscopy (SEM) showed that the microcapsules were a regular spherical shape with particle sizes ranging from 0.5 to 5 mu m. The release of the microcapsules with different core/wall ratios exhibited an initial rapid release phase and a following slow release phase, which obeyed Rigter-Peppas release kinetics. The antibacterial activity of the microcapsules was evaluated by both disc-diffusion and minimal inhibitory concentration methods, revealing that the loaded microcapsules had a stronger antibacterial effect against Escherichia coli and Staphylococcus aureus than the hollow microcapsules. The microcapsules can be applied in medicine as a drug release system, in the textile industry as an antibacterial agent, and in the perfume industry as a fixative.