A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions.
A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions.
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DOI：
10.1038/ncb2924
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发表时间：
2014-03
影响因子：
21.3
通讯作者：
Petritsch C
中科院分区：
文献类型：
--
作者：
Lerner RG;Petritsch C
干细胞和祖细胞的缺陷性不对称细胞分裂通过一种很大程度上未知的机制与肿瘤发生相关。涉及 Snail、microRNA-146a 和 Numb 的信号轴现在被证明可以调节结直肠癌干细胞中对称和不对称细胞分裂之间的转换。
Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.