Angiogenesis: a harmonized target for recovery after stroke.
Angiogenesis: a harmonized target for recovery after stroke.
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DOI：
10.1161/strokeaha.111.642710
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发表时间：
2012-08
期刊：
影响因子：
8.3
通讯作者：
Fagan SC
中科院分区：
文献类型：
--
作者：
Ergul A;Alhusban A;Fagan SC
现在认识到，用于恢复的新兴治疗策略必须包括脑血管系统，并且血管生成的诱导将刺激内源性恢复机制，包括神经发生、突触发生以及神经元和突触可塑性。这些事件都涉及缺血事件后大脑的长期修复和恢复过程。最近几篇优秀的综述提供了关于卒中后血管生成的机制和分子靶点的详细信息。1，2本综述的目的是评估血管生成是缺血性卒中后恢复的靶点的证据。
It is now appreciated that emerging therapeutic strategies for recovery must include the cerebral vasculature and that induction of angiogenesis will stimulate endogenous recovery mechanisms, including neurogenesis, synaptogenesis, and neuronal and synaptic plasticity. These events are all involved in the long-term repair and restoration process of the brain after an ischemic event. Several recent excellent reviews provided detailed information on the mechanisms and molecular targets for angiogenesis after stroke. 1, 2 The purpose of this review is to evaluate the evidence that angiogenesis is a target for recovery after an ischemic stroke.