Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring
Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring
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DOI：
10.1161/01.cir.0000139843.05436.a0
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发表时间：
2004-08-31
期刊：
影响因子：
37.8
通讯作者：
Taylor, P
中科院分区：
文献类型：
--
作者：
Khan, I;Dekou, V;Taylor, P
以人群为背景的研究表明，当产后饮食仍然不理想时，胎儿对母亲饮食不平衡的适应性反应会带来生存益处，但当产后营养得到改善时，胎儿对心血管疾病的易感性会增加。我们在啮齿动物模型中研究了“预测适应性”反应，在该模型中，脂肪喂养的母鼠的成年后代出现了代谢综合征的特征。方法和结果-斯普拉格-道利大鼠在整个怀孕和断奶期间被喂食富含脂肪的饮食或正常食物。对标准饲料 (FC) 或高脂肪饮食 (FF) 饲养的脂肪喂养母鼠的 180 日龄后代以及以食物饲养的饲料喂养母鼠 (CON) 的后代测定血管内皮功能和血压。男性和女性 FC 中小肠系膜动脉内皮依赖性乙酰胆碱扩张受损（通过 ANOVA，P
Background-Population-based studies suggest that fetal adaptive responses to maternal dietary imbalance confer survival benefit when the postnatal diet remains suboptimal but increase susceptibility to cardiovascular disease when postnatal nutrition is improved. We have investigated "predictive adaptive" responses in a rodent model in which adult offspring of fat-fed dams develop characteristics of the metabolic syndrome.Methods and Results-Sprague-Dawley rats were fed a fat-rich diet or normal chow throughout pregnancy and weaning. Vascular endothelial function and blood pressure were determined in 180-day-old offspring of fat-fed dams raised on standard chow (FC) or on the fat-rich diet (FF) and in offspring of chow-fed dams raised on chow (CON). Small mesenteric artery endothelium-dependent dilation to acetylcholine was impaired in male and female FC (by ANOVA, P