AROMATASE-ACTIVITY IN ADIPOSE-TISSUE FROM BREAST QUADRANTS - A LINK WITH TUMOR SITE
AROMATASE-ACTIVITY IN ADIPOSE-TISSUE FROM BREAST QUADRANTS - A LINK WITH TUMOR SITE
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DOI：
10.1136/bmj.296.6624.741
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发表时间：
1988-03-12
影响因子：
105.7
通讯作者：
MILLER, WR
中科院分区：
文献类型：
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作者：
ONEILL, JS;ELTON, RA;MILLER, WR
为了确定乳房内局部雌激素生物合成的重要性，对乳腺癌患者连续 12 次乳房切除术的乳房象限的脂肪组织中的芳香酶活性进行了测量。在所有样本中均检测到活性（范围为 3.6-35.0 fmol 雌激素/毫克蛋白质/小时），但不仅在不同患者之间而且在个体乳房象限之间也存在很大差异。乳房中的最高活性总是出现在含有肿瘤的象限中，而活性最低的象限与肿瘤的存在无关。这些结果提供了乳腺脂肪组织与乳腺癌之间存在显着关系的证据。发生这种关联是否是因为乳腺肿瘤更有可能在雌激素生物合成增强的区域发生，还是因为它们向局部环境分泌能够刺激雌激素生物合成的因子，仍有待确定。
To determine the importance of local oestrogen biosynthesis within the breast, aromatase activity was measured in adipose tissue from the breast quadrants of 12 consecutive mastectomies from patients with breast cancer. Activity was detected in all samples (range 3.6-35.0 fmol oestrogen/mg protein/h) but varied considerably not only among different patients but also among the quadrants of individual breasts. The highest activity in a breast was always found in a quadrant that contained tumour, whereas quadrants with the lowest activity were never associated with the presence of tumour. These results provide evidence of a significant relation between breast adipose tissue and breast cancer. Whether such an association occurs because breast tumours are more likely to develop in areas with enhanced oestrogen biosynthesis or because they secrete into their local environment factors capable of stimulating oestrogen biosynthesis remains to be determined.