The reductions in sweetened milk intake induced by interleukin-1 and endotoxin are not prevented by chronic antidepressant treatment
The reductions in sweetened milk intake induced by interleukin-1 and endotoxin are not prevented by chronic antidepressant treatment
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DOI：
10.1159/000049021
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发表时间：
2001-01-01
影响因子：
2.4
通讯作者：
Swiergiel, AH
中科院分区：
文献类型：
--
作者：
Dunn, AJ;Swiergiel, AH
给啮齿类动物施用白细胞介素-1（IL-1）和内毒素（脂多糖，LPS）可以减少食物摄入，这是一种类似于在人类抑郁症中观察到的食欲下降的行为反应。已知IL-1和LIPS影响涉及去甲肾上腺素和5-羟色胺的脑神经传递，这两者都与人类的进食行为和抑郁症的药物治疗有关。慢性抗抑郁治疗减弱LPS诱导的大鼠抑郁进食的能力已被引用为细胞因子可能参与人类抑郁症的证据。因此，我们研究了三环类抗抑郁药丙咪嗪和新型抗抑郁药文拉法辛长期治疗对腹膜内注射IL-1 β和LPS挑战的甜牛奶摄入量的影响。用丙咪嗪（10 mg/kg，每日一次或两次）或文拉法辛（10和20 mg/kg/天）对小鼠进行慢性（2至8周）治疗，未显著改变对mIL-1 β或LPS的反应导致的牛奶摄入量减少。在一些实验中，慢性丙咪嗪轻微降低体重和轻微增加牛奶摄入量，但不食物颗粒摄入量。文拉法辛没有这些作用。方差分析未表明抗抑郁药与IL-1或LPS治疗之间存在任何显著的相互作用。这些结果表明，抗抑郁药的慢性治疗并没有显着改变对IL-1或LPS的反应，在小鼠甜牛奶模型的疾病行为。版权所有（C）2001 S. Karger AG，巴塞尔。
Administration of interleukin-1 (IL-1) and endotoxin (lipopolysaccharide, LPS) to rodents can decrease food intake, a behavioral response resembling the diminution of appetite observed in human depression. IL-1 and LIPS are known to affect cerebral neurotransmission involving norepinephrine and serotonin, both of which have been implicated in feeding behavior and in the pharmacotherapy of depression in man. The ability of chronic antidepressant treatment to attenuate LPS-induced depressed feeding in rats has been cited as evidence that cytokines may be involved in human depression. Thus, we studied the effects of chronic treatment with the tricyclic antidepressant, imipramine, and the novel antidepressant, venlafaxine, on the sweetened milk intake challenged with intra peritoneally injected IL-1beta and LPS. Chronic (from 2 to 8 weeks) treatment of the mice with imipramine (10 mg/kg once or twice daily) or venlafaxine (10 and 20 mg/kg/day) did not significantly alter the decreases in milk intake in response to mIL-1beta or LPS. In some experiments, chronic imipramine slightly decreased body weight and slightly increased milk intake, but not food pellet intake. Venlafaxine had none of these effects. Analysis of variance did not indicate any significant interactions between the antidepressant and IL-1 or LPS treatments. These results indicate that chronic treatment with antidepressants does not significantly alter the responses to IL-1 or LPS in the mouse sweetened milk model of sickness behavior. Copyright (C) 2001 S. Karger AG, Basel.