A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori-associated gastric or duodenal ulcer
A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori-associated gastric or duodenal ulcer
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DOI：
10.1046/j.1365-2036.2001.01109.x
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发表时间：
2001-12-01
影响因子：
7.6
通讯作者：
Malfertheiner, P
中科院分区：
文献类型：
--
作者：
Leodolter, A;Kulig, M;Malfertheiner, P
目的：目的：比较幽门螺杆菌根除治疗消化性溃疡的有效性，方法：选取符合标准的24个相关随机对照试验和随机对照试验。仅考虑基于质子泵抑制剂的根除试验来评估根除疗效和溃疡愈合。为了确定复发率，考虑了所有独立于根除治疗方案的试验。结果：分析了2102例患者的数据，比较了胃溃疡和十二指肠溃疡。胃溃疡和十二指肠溃疡患者在根除率（总结的比值比，1.23; 95%置信区间，0.98-1.55）或溃疡复发率方面没有发现统计学差异，无论是成功的H。pylori根除患者（总结优势比，0.69; 95%可信区间，0.26-1.84）或H.幽门螺杆菌根除患者（总结优势比，1.48; 95%置信区间，0.85- 2.56）。由于异质性，治愈率不具有可比性。结论：根除H。幽门螺杆菌感染可治愈胃溃疡和十二指肠溃疡，治愈率相似。这表明H.幽门螺杆菌是消化性溃疡病的关键因素，与溃疡部位无关。
Aim: To compare the effectiveness of Helicobacter pylori eradication in curing peptic ulcer disease in trials involving both gastric ulcer and duodenal ulcer.Methods: Twenty-four relevant randomized controlled trials and randomized comparative trials met the predefined selection criteria. Only proton pump inhibitor-based eradication trials were considered for the evaluation of eradication efficacy and ulcer healing. For the determination of relapse rates, all trials independent of the eradication therapy regimen were considered.Results: Data from 2102 patients were analysed comparing gastric ulcer with duodenal ulcer. No statistical differences between gastric ulcer and duodenal ulcer patients were found with regard to eradication rates (summarized odds ratio, 1.23; 95% confidence interval, 0.98-1.55) or ulcer relapse rates, whether in successfully H. pylori eradicated patients (summarized odds ratio, 0.69; 95% confidence interval, 0.26-1.84) or unsuccessfully H. pylori eradicated patients (summarized odds ratio, 1.48; 95% confidence interval, 0.85- 2.56). Owing to heterogeneity, healing rates were not comparable.Conclusions: The eradication of H. pylori infection cures both gastric and duodenal ulcer, and the cure rates are similar. This suggests that H. pylori is the key factor in peptic ulcer disease independent of the ulcer site.