Vancomycin treatment of bacteremia caused by oxacillin-resistant Staphylococcus aureus: comparison with beta-lactam antibiotic treatment of bacteremia caused by oxacillin-sensitive Staphylococcus aureus.
Vancomycin treatment of bacteremia caused by oxacillin-resistant Staphylococcus aureus: comparison with beta-lactam antibiotic treatment of bacteremia caused by oxacillin-sensitive Staphylococcus aureus.
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DOI：
10.1093/infdis/147.1.137
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
D. Craven;N. Kollisch;Candace R. Hsieh;Michael G. Connolly;W. R. Mccabe
中科院分区：
文献类型：
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作者：
D. Craven;N. Kollisch;Candace R. Hsieh;Michael G. Connolly;W. R. Mccabe
将 36 个月内发生的 29 次苯唑西林和氨基糖苷耐药金黄色葡萄球菌 (OARSA) 引起的菌血症与 29 次苯唑西林敏感金黄色葡萄球菌 (OSSA) 引起的菌血症的流行病学和治疗进行了比较。 OSSA 引起的菌血症患者年龄较小（P 小于 0.05），且因急性创伤而入院的比例更高（P 小于 0.01）。使用万古霉素治疗的 OARSA 菌血症患者在持续菌血症后 1 个月的总生存率为 74%，而使用 β-内酰胺抗生素治疗的 OSSA 菌血症患者的总生存率为 70%。结果表明，万古霉素是治疗 OARSA 引起的菌血症的有效抗生素，并且其有效性与治疗 OSSA 引起的菌血症的 β-内酰胺抗生素相当。
The epidemiology and therapy of 29 episodes of bacteremia caused by oxacillin- and aminoglycoside-resistant Staphylococcus aureus (OARSA) were compared with 29 episodes of bacteremia due to oxacillin-sensitive S. aureus (OSSA) that occurred during a 36-month period. Patients with bacteremia due to OSSA were younger (P less than 0.05) and were admitted more frequently with acute traumatic injury (P less than 0.01). The overall survival rate one month after persistent bacteremia was 74% for patients with OARSA bacteremia treated with vancomycin compared with 70% for patients with OSSA bacteremia treated with a beta-lactam antibiotic. The results indicate that vancomycin is an effective antibiotic for the treatment of bacteremia caused by OARSA and suggest that its effectiveness is comparable to that of beta-lactam antibiotic treatment of bacteremia due to OSSA.