MODELING AND HEMODYNAMIC SIMULATION OF HUMAN ARTERIAL STENOSIS VIA TRANSMISSION LINE MODEL
MODELING AND HEMODYNAMIC SIMULATION OF HUMAN ARTERIAL STENOSIS VIA TRANSMISSION LINE MODEL
复制标题
通过传输线模型对人体动脉狭窄进行建模和血流动力学模拟
DOI：
10.1142/s0219519416500676
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发表时间：
2016-08-01
影响因子：
0.8
通讯作者：
Zhao, Mingfu
中科院分区：
文献类型：
--
作者：
Xiao, Hanguang;Avolio, Alberto;Zhao, Mingfu
动脉狭窄在心血管疾病的发生、发展过程中起着关键作用。基于55段动脉树传输线模型，研究了动脉狭窄对人体动脉树整体血流动力学特性的影响。模拟不同部位、不同程度、不同长度的动脉狭窄，探讨人体动脉树内血压和血流波形的变化。狭窄程度为50%-90%表示轻度、中度或重度狭窄。选择三个有代表性的狭窄部位：主动脉、颈动脉和髂动脉。狭窄长度规定为1 cm至4 cm。模拟结果与文献数据进行了比较。计算踝肱指数（ABI），分析其与狭窄部位的关系。结果表明：主动脉狭窄对上游动脉血压和血流波形的影响大于下游动脉;分支动脉狭窄对下游动脉血压和血流波形的影响大于上游动脉。当狭窄程度增加到80%时，血压和血流波形受到明显影响。狭窄长度引起狭窄入口和出口的压力和流量波形发生明显变化。通过与文献的比较表明，该方法是模拟和研究人体动脉狭窄血流动力学的一种可行的工具。
Arterial stenosis plays a key role in the development and formation of cardiovascular diseases. The effects of arterial stenosis on the global hemodynamic characteristics of human artery tree were studied based on a previously proposed transmission line model of 55 segment arterial tree. Different position, degree and length of the arterial stenosis were simulated to discuss the changes of blood pressure and flow waveform in human arterial tree. The stenosis degree of 50% to 90% were specified to represent a mild, moderate or severe stenosis. Three representative stenosis positions: aorta, carotid and iliac artery were selected. The stenosis length was specified to be 1cm to 4cm. The results of simulation were compared with the literature data. And ankle branchial index (ABI) was calculated to show its relationship with the stenosis position. The results showed that the influence of aorta stenosis on the blood pressure and flow waveforms of upstream artery is more obvious than those of downstream artery; branch artery stenosis has more influence on the blood pressure and flow waveforms of downstream artery than those of upstream artery. When the stenosis degree increased to 80%, the blood pressure and flow waveforms are affected significantly. The stenosis length causes a obvious change in the pressure and flow waveforms of stenosis inlet and outlet. The comparisons of literature and ABI demonstrated that the modeling method is a feasible tool to simulate and study the hemodynamics of the human artery stenosis.