NOCTURNAL EXERCISE PHASE DELAYS CIRCADIAN-RHYTHMS OF MELATONIN AND THYROTROPIN SECRETION IN NORMAL MEN
NOCTURNAL EXERCISE PHASE DELAYS CIRCADIAN-RHYTHMS OF MELATONIN AND THYROTROPIN SECRETION IN NORMAL MEN
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DOI：
10.1152/ajpendo.1994.266.6.e964
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发表时间：
1994-06-01
影响因子：
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通讯作者：
VANCAUTER, E
中科院分区：
文献类型：
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作者：
VANREETH, O;STURIS, J;VANCAUTER, E
为了确定单次体育活动是否能够诱导人类昼夜节律的快速相移，对17名受试者进行了两次恒定常规条件下的研究，一次是在没有刺激的情况下，另一次是在3小时的夜间运动脉冲中断恒定常规条件下。持续监测血浆皮质醇、促甲状腺激素（TSH）和褪黑激素以及体温的变化，以得出昼夜节律相位位置的估计。在运动暴露后第1天测量相移。运动时间在最低体温节律前后的-5小时至+4小时之间。夜间运动与褪黑激素和TSH节律的1- 2小时相延迟有关，当运动在夜间后期和清晨进行时，延迟的大小倾向于较小。这些数据表明，非光刺激可能对人体昼夜节律起搏器产生相移效应。
To determine whether a single episode of physical activity is capable of inducing rapid phase shifts in human circadian rhythms, 17 subjects were studied two times under constant routine conditions, once in the absence of stimulus and once with a 3-h nighttime pulse of exercise interrupting the constant routine conditions. The profiles of plasma cortisol, thyrotropin (TSH), and melatonin and of body temperature were monitored continuously to derive estimations of circadian phase position. The phase shifts were measured on the Ist day after exercise exposure. The timing of the exercise period ranged from -5 h to +4 h around the time of the minimum body temperature rhythm. Nighttime exercise was associated with 1- to 2-h phase delays of both the melatonin and TSH rhythms, with the size of the delays tending to be smaller when the exercise was presented in the latter part of the nighttime period and in the early morning. These data demonstrate that nonphotic stimuli may exert phase-shifting effects on the human circadian pacemaker.