Two human c-onc genes are located on the long arm of chromosome 8.
Two human c-onc genes are located on the long arm of chromosome 8.
复制标题
两个人类 c-onc 基因位于 8 号染色体的长臂上。
DOI：
10.1073/pnas.79.24.7842
复制
发表时间：
1982
影响因子：
11.1
通讯作者：
Hayward,WS
中科院分区：
文献类型：
--
作者：
Neel,BG;Jhanwar,SC;Chaganti,RS;Hayward,WS
我们使用原位染色体杂交技术在人类减数分裂粗线期和体细胞中期染色体上绘制了两种RNA肿瘤病毒转化基因的人类细胞对应物（c-onc基因）。我们发现人类c-mos基因位于8号染色体上对应体细胞图谱8q22带的位置。人类 c-myc 基因位于 8 号染色体 8q24 位置。此前已有报道称，8 号染色体长臂上的这些区域涉及急性非淋巴细胞白血病 M-2 亚型中发现的特定易位。伯基特淋巴瘤和其他形式的非霍奇金淋巴瘤，以及易患肾细胞癌的家族性异常。这些结果表明人类 c-mos 或 c-myc 基因的易位可能与肿瘤转化有因果关系。
We have used in situ chromosome hybridization techniques to map the human cellular counterparts (c-onc genes) of the transforming genes of two RNA tumor viruses on human meiotic pachytene and somatic metaphase chromosomes. We find that the human c-mos gene is located on chromosome 8 at a position corresponding to band 8q22 on the somatic map. The human c-myc gene is found on chromosome 8 at position 8q24. These regions on the long arm of chromosome 8 have been previously reported to be involved in specific translocations found in the M-2 subset of acute nonlymphoblastic leukemias. Burkitt lymphoma, and other forms of non-Hodgkin lymphoma, and a familial abnormality that predisposes to renal cell carcinoma. These results suggest that translocations of the human c-mos or c-myc genes may be causally related to neoplastic transformation.