Formation of C-C bonds via ruthenium-catalyzed transfer hydrogenation().
Formation of C-C bonds via ruthenium-catalyzed transfer hydrogenation().
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DOI：
10.1351/pac-con-11-10-18
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Krische MJ
中科院分区：
文献类型：
--
作者：
Moran J;Krische MJ
在醛的存在下，Ru催化的各种π-不饱和反应物的转移氢化反应产生了羰基加成产物。伯醇在相同的π-不饱和反应物存在下脱氢，得到相同的羰基加成产物。这样，在没有化学计量比的有机金属试剂或金属还原剂的情况下，从醇或醛的氧化水平实现了羰基加成。本文讨论了Ru催化的C-C成键转移氢化反应的发现以及非对映体和对映体选择性变体的最新发展。
Ruthenium-catalyzed transfer hydrogenation of diverse π-unsaturated reactants in the presence of aldehydes provides products of carbonyl addition. Dehydrogenation of primary alcohols in the presence of the same π-unsaturated reactants provides identical products of carbonyl addition. In this way, carbonyl addition is achieved from the alcohol or aldehyde oxidation level in the absence of stoichiometric organometallic reagents or metallic reductants. In this account, the discovery of ruthenium-catalyzed C–C bond-forming transfer hydrogenations and the recent development of diastereo- and enantioselective variants are discussed.