Neural deficits in anticipatory and consummatory reward processing are uniquely associated with current depressive symptoms during adolescence.
Neural deficits in anticipatory and consummatory reward processing are uniquely associated with current depressive symptoms during adolescence.
复制标题
预期和完成性奖励处理的神经缺陷与青春期当前的抑郁症状独特相关。
DOI：
10.1111/psyp.14257
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
Hajcak,Greg
中科院分区：
文献类型：
--
作者：
Thompson,Brittney;Santopetro,NicholasJ;Brush,ChristopherJ;Foti,Dan;Hajcak,Greg
奖励加工的完成阶段的缺陷与抑郁症状和风险增加有关;然而，很少有研究还研究了奖励加工与抑郁症的其他方面。在本研究中，121名青少年（法师= 13.1，Min = 11.14; Max = 15.12; 54%男性）的社区样本完成了自我报告问卷，以评估抑郁症状和货币激励延迟（MID）任务，同时记录EEG。结果表明，减少线索P300以及减少奖励积极性（RewP）和反馈消极性（FN）分别获得和失去反馈，与抑郁症状增加有关;另一方面，SPN和反馈P300与抑郁症状无关。探索性多元回归分析显示，减少的货币线索-P300，减少的RewP，和减少的（即，较少负性）FN，所有这些都解释了抑郁症状的独特差异。目前的研究表明，降低cue-P300，RewP和FN振幅可能反映了抑郁症状增加的青少年在奖励处理方面的明显缺陷。值得注意的是，这项研究是第一个利用MID任务在青少年中与抑郁症状相关的研究之一，可以更深入地了解青少年中抑郁情绪增加的青少年在奖励处理方面的个体差异。
Deficits within the consummatory phase of reward processing are associated with increased depression symptoms and risk; however, few studies have also examined other aspects of reward processing in relation to depression. In the current study, a community sample of 121 adolescents (Mage= 13.1, Min = 11.14; Max = 15.12; 54% male) completed self‐report questionnaires to assess depressive symptoms and the monetary incentive delay (MID) task while EEG was recorded. Results indicated that a reduced cue‐P300 as well as a reduced reward positivity (RewP) and feedback negativity (FN) to gain and loss feedback, respectively, were associated with increased depressive symptoms; on the other hand, SPN and feedback P300 were unrelated to depressive symptoms. An exploratory multiple regression analysis revealed that a reduced money cue‐P300, a reduced RewP, and a reduced (i.e., less negative) FN, all explained unique variance in depressive symptoms. The current study demonstrates that reduced cue‐P300, RewP, and FN amplitudes may reflect distinct deficits in reward processing among adolescents with increased depressive symptoms. Notably, this study is one of the first to leverage the MID task in adolescents in relation to depressive symptoms, allowing for a more in‐depth view of the individual differences in reward processing among adolescents with increased depressive symptomatology.