Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) Protocol
Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) Protocol
复制标题
DOI：
10.1186/1745-6215-12-124
复制
发表时间：
2011-05-17
期刊：
影响因子：
2.5
通讯作者：
Gholkar, Anil R.
中科院分区：
文献类型：
--
作者：
Mendelow, A. David;Gregson, Barbara A.;Gholkar, Anil R.
工作背景：在自发性脑内出血的范围内，有一些大出血或占位性出血的患者需要手术治疗神经功能恶化，而另一些小血肿的患者则需要保守治疗。在这两个极端之间，病人的管理是平衡的。特别是有证据表明，有脑叶血肿且无脑室内出血的患者可能受益于血肿清除术。斯蒂奇II研究将确定是否在选定的患者的血肿早期手术疏散的政策将改善结果相比，最初的保守治疗的政策。方法/设计：一个国际多中心随机平行组试验。只有那些神经外科医生认为早期开颅手术与早期保守治疗相比的好处是平衡的患者才有资格。所有患者都必须进行CT扫描，确认自发性脑叶内出血（
Background: Within the spectrum of spontaneous intracerebral haemorrhage there are some patients with large or space occupying haemorrhage who require surgery for neurological deterioration and others with small haematomas who should be managed conservatively. There is equipoise about the management of patients between these two extremes. In particular there is some evidence that patients with lobar haematomas and no intraventricular haemorrhage might benefit from haematoma evacuation. The STICH II study will establish whether a policy of earlier surgical evacuation of the haematoma in selected patients will improve outcome compared to a policy of initial conservative treatment.Methods/Design: an international multicentre randomised parallel group trial. Only patients for whom the treating neurosurgeon is in equipoise about the benefits of early craniotomy compared to initial conservative treatment are eligible. All patients must have a CT scan confirming spontaneous lobar intracerebral haemorrhage (