Interactions among multiple genomes: Tsetse, its symbionts and trypanosomes
Interactions among multiple genomes: Tsetse, its symbionts and trypanosomes
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DOI：
10.1016/j.ibmb.2005.02.012
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发表时间：
2005-07-01
影响因子：
3.8
通讯作者：
Rio, RVM
中科院分区：
文献类型：
--
作者：
Aksoy, S;Rio, RVM
虫媒疾病造成沉重的公共卫生负担，并对牲畜和农业造成毁灭性影响。迄今为止，控制已被证明是极其困难的。困扰撒哈拉以南非洲的一种这样的疾病是由原生动物非洲锥虫（锥虫种）引起的，并由采采蝇（双翅目：舌蝇科）传播。本报告描述了采采蝇的生物学及其与锥虫及其共生体的相互作用。采采蝇可以容纳多达三种不同的微生物共生体，包括两种肠道菌（Wigglesworthia舌菌和Sodalis舌菌）以及兼性沃尔巴赫氏体感染，它们会影响宿主的生理。最近对专性共生体Wigglesworthia基因组的研究揭示了其与采采蝇宿主物种长期共同进化历史的特征。对类似评论的Sodalis与自由生活的肠道的比较分析提供了适应宿主环境（生理学和生态学）的例子，反映了在向共生生活方式过渡过程中的基因组剪裁事件。从应用的角度来看，在共生体的基因组和发育生物学方面积累的广泛知识，加上我们在体外表达这些微生物中的外源基因和用这些工程微生物重新填充采采肠道的能力，现在提供了一种干扰宿主生理性状的方法，这有助于载体能力的提高，有望成为疾病管理的新工具。(c) 2005 Elsevier Ltd版权所有。
Insect-borne diseases exact a high public health burden and have a devastating impact on livestock and agriculture. To date, control has proved to be exceedingly difficult. One such disease that has plagued sub-Saharan Africa is caused by the protozoan African trypanosomes (Trypanosoma species) and transmitted by tsetse flies (Diptera: Glossinidae). This presentation describes the biology of the tsetse fly and its interactions with trypanosomes as well as its symbionts. Tsetse can harbor up to three distinct microbial symbionts, including two enterics (Wigglesworthia glossinidia and Sodalis glossinidius) as well as facultative Wolbachia infections, which influence host physiology. Recent investigations into the genome of the obligate symbiont Wigglesworthia have revealed characteristics indicative of its long co-evolutionary history with the tsetse host species. Comparative analysis of the commensal-like Sodalis with free-living enterics provides examples of adaptations to the host environment (physiology and ecology), reflecting genomic tailoring events during the process of transitioning into a symbiotic lifestyle. From an applied perspective, the extensive knowledge accumulated on the genomic and developmental biology of the symbionts coupled with our ability to both express foreign genes in these microbes in vitro and repopulate tsetse midguts with these engineered microbes now provides a means to interfere with the host physiological traits which contribute to vector competence promising a novel tool for disease management. (c) 2005 Elsevier Ltd. All rights reserved.