Dopamine receptor (DRD2) genotype-dependent effects of nicotine on attention and distraction during rapid visual information processing
Dopamine receptor (DRD2) genotype-dependent effects of nicotine on attention and distraction during rapid visual information processing
复制标题
DOI：
10.1080/14622200500125245
复制
发表时间：
2005-06-01
影响因子：
4.7
通讯作者：
Huggenvik, JI
中科院分区：
文献类型：
--
作者：
Gilbert, DG;Izetelny, A;Huggenvik, JI
在习惯性吸烟者中评估尼古丁、干扰物类型和多巴胺2型受体（DRD 2）基因型对快速视觉信息处理（RVIP）任务绩效的影响。四个RVIP任务不同的分心物位置（中央与外围）和分心物类型（数字与情感）。每个参与者在两个不同的日子里完成每项任务，一次是戴着活性尼古丁贴片，一次是戴着安慰剂贴片。总的来说，尼古丁贴片对靶序列的检测更准确，反应时间更快;然而，这些影响因干扰物类型和基因型而异。尼古丁加速反应时间与左视野（LVF）比右视野（RVF）的情绪干扰，但加速反应时间与RVF比LVF数字干扰，特别是当干扰数字匹配的目标序列的数字奇数或偶数。尼古丁倾向于促进表现在个人至少有一个A1等位基因比纯合子A2 A2个人，特别是与数字干扰提交给左半球。尼古丁比其他类型的刺激更倾向于减少负面刺激引起的分心。几乎没有观察到性别差异。结果的总体模式与尼古丁调节选择性注意力或随后的信息处理的方式一致，这种方式部分取决于任务干扰物的情感与数字性质，DRD 2基因型和最初处理干扰物的大脑半球（干扰物的视野）。
The effects of nicotine, distractor type, and dopamine type-2 receptor (DRD2) genotype on rapid visual information processing (RVIP) task performance were assessed in habitual smokers. Four RVIP tasks differed in terms of distractor location (central vs. peripheral) and distractor type (numeric vs. emotional). Each participant performed each of the tasks on two different days, once while wearing an active nicotine patch and once while wearing a placebo patch. Overall, the nicotine patch produced more accurate detection of and faster reaction times to target sequences; however, these effects varied with distractor type and genotype. Nicotine speeded reaction time more with left-visual-field (LVF) than right-visual-field (RVF) emotional distractors but speeded reaction time more with RVF than LVF numeric distractors, especially when the distractor digit matched the target sequence in terms of numeric oddness or evenness. Nicotine tended to facilitate performance more in individuals with at least one A1 allele than in homozygous A2A2 individuals, especially with numeric distractors presented to the left hemisphere. Nicotine tended to reduce distraction by negative stimuli more than other types of stimuli. Few gender differences were observed. The overall pattern of results was consistent with the view that nicotine modulates selective attention or subsequent information processing in a manner that depends partly on the emotional versus numeric nature of task distractors, DRD2 genotype, and the brain hemisphere that initially processes the distractors (visual field of distractor).