Sporadic cases of acute autochthonous hepatitis E in Spain
Sporadic cases of acute autochthonous hepatitis E in Spain
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DOI：
10.1016/j.jhep.2004.03.013
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发表时间：
2004-07-01
影响因子：
25.7
通讯作者：
Girones, R
中科院分区：
文献类型：
--
作者：
Buti, M;Clemente-Casares, P;Girones, R
背景/目的：在工业化国家，戊型肝炎病毒(HEV)感染很少见，由于现有检测方法的实用性不高，其诊断也很困难。方法：我们研究了11例抗HEV抗体阳性的急性肝炎患者中急性HEV感染标志物的存在。结果：3例确诊为急性戊型肝炎，8例确诊为戊型肝炎，2例既往感染HEV，1例无法确定。从3例患者血清中鉴定出3种不同的HEV毒株。其中2株为3型，1株为输入型。结论：本地区存在部分本地散发性急性戊型肝炎病例和1例输入性病例，HEV病毒学和血清学标志物具有暂时性。(C)2004年欧洲肝脏研究协会。爱思唯尔出版，版权所有。
Background/Aims: In industrialized countries hepatitis E virus (HEV) infection is rare and its diagnosis is difficult because the utility of available tests is not well established.Methods: We studied the presence of acute HEV infection markers in a cluster of 11 cases of acute hepatitis with IgG anti-HEV antibodies.Results: Three cases were confirmed as acute hepatitis E and 8 as presumptive hepatitis E, two as a past HEV infection and one could not be determined. Three different HEV strains were identified in serum from 3 patients. Two strains belonged to genotype 3, the predominant genotype found in local urban sewage and the other strain belonged to genotype 1 and was considered an imported strain.Conclusions: Our findings demonstrate the presence of some autochthonous, sporadic acute hepatitis E cases as well as an imported case in our area and the transitory nature of virological and serological markers for HEV. (C) 2004 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.