Prostaglandins and the kidney.
Prostaglandins and the kidney.
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前列腺素和肾脏。
DOI：
10.1159/000166703
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发表时间：
1983
影响因子：
4.2
通讯作者：
Ferris,TF
中科院分区：
文献类型：
--
作者：
Ferris,TF
大量的实验和临床证据表明，肾脏不仅具有通过肾素-血管紧张素11-醛固酮系统升高动脉压的潜能，而且还具有降血压的功能。这在Goldblatt等人的最初实验中是显而易见的。[1]当他们发现肾动脉狭窄后只有短暂的和不可预测的高血压，而对侧肾脏是完整的。相反，当切除对侧肾脏时，必然会发生严重和持续的高血压。在Goldblatt实验的2年前，Chanaland和Ferris [2]的实验证明了肾脏质量的减少会导致高血压，从而提高了Kidн ney的抗高血压作用。在20世纪40年代后期，在大鼠[3]和狗[4]中进行的后续实验表明，双侧肾切除术后血压升高，尽管给予盐和水时高血压更严重，但体积扩张不是高血压反应所必需的。Grollman等人的实验。[4]其中比较了输尿管转移到下腔静脉的狗和双侧肾切除的动物的血压，证明肾的存在减轻了尿毒症的高血压。由于两组动物的体积扩张相等，因此肾衰竭性高血压的概念得到了认可。
A great deal of experimental and clinical evidence has indicated that the kidney not only has the potential for increasing arterial pressure through the renin-angiotensin 11-aldosterone system but also has a blood pressure-lowн ering function. This was evident in the initial experiн ments of Goldblatt et al.[1] when they found only tranн sient and unpredictable hypertension following renal arн tery'constriction when the contralateral kidney was left intact. In contrast, when the contralateral kidney was removed, a severe and sustained hypertension would invariably occur. The anti-hypertensive effect of the kidн ney had been raised by the experiments of Chanutin and Ferris [2] 2 years previous to Goldblatt's experiment when they demonstrated that a reduction in renal mass caused hypertension. Subsequent experiments in the rat [3] and dog [4] in the late 1940s demonstrated that folн lowing bilateral nephrectomy blood pressure rose and although the hypertension was worse when salt and water was administered, volume expansion was not necessary for the hypertensive response. The experiments of Grollman et al.[4] in which blood pressure was compared in dogs with ureters diverted into the inferior vena cava and in animals having a bilateral nephrectomy demonstrated that the presence of the kidneys lessened the hypertension in uremia. Since volume expansion was equal in both groups of animals, the concept of renoprival hypertension became recognized.
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3-羟基-3-甲基戊二酰辅酶 A 合酶缺陷的哺乳动物细胞突变体的分离和表征。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Schnitzer-Polokoff,R;vonGunten,C;Logel,J;Torget,R;Sinensky,M
通讯作者：
Sinensky,M
一种新型类固醇生物合成抑制剂[11]
影响因子：
15
作者：
J. Nelson;M. Czarny;T. A. Spencer;J. S. Limanek;K. McCrae;Ta
通讯作者：
Ta
DOI：
10.1111/j.1432-1033.1975.tb03933.x
发表时间：
1975-01-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
NILSSON, A
通讯作者：
NILSSON, A
DOI：
10.1073/pnas.72.8.2925
发表时间：
1975-01-01
影响因子：
11.1
作者：
BROWN, MS;DANA, SE;GOLDSTEIN, JL
通讯作者：
GOLDSTEIN, JL
影响因子：
6.5
作者：
M. Brown;J. Goldstein
通讯作者：
M. Brown;J. Goldstein