Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing
Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing
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人脱细胞羊膜植入用于下第三鼻重建：一种有前景的促进伤口愈合的疗法
DOI：
10.1186/s41038-018-0136-x
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发表时间：
2018-12-18
期刊：
影响因子：
5.3
通讯作者：
Huang, Yong-Can
中科院分区：
文献类型：
--
作者：
Xue, Si-Liang;Liu, Kai;Huang, Yong-Can
鼻子的下三分之一是面部最重要的美容单位之一，其重建技术仍然是一个很大的挑战。作为修复或再生鼻组织的一种替代方法，基于生物材料的策略已经得到了广泛的研究。本研究的目的是确定人脱细胞羊膜（HAAM）修复人鼻下三分之一全层缺损的安全性和有效性。方法本研究纳入2012 - 2016年接受鼻下三分之一皮损切除术的180例患者；其中92例采用HAAM联合凡士林纱布治疗，88例仅采用凡士林纱布治疗。术中记录止血时间和手术时间；术后观察疼痛消失时间、结痂形成时间、创面愈合时间及创面愈合率。结果HAAM植入术后即刻止血时间缩短，疼痛消失加快。与对照组相比，植入HAAM的患者术后结痂形成和脱落明显加快。当病变直径超过5mm时，发现HAAM植入可以促进伤口愈合，但当直径小于5mm时则没有这种增强作用。此外，HAAM植入可显著减少术后出血、伤口感染和疤痕形成。结论shaam辅助修复下三鼻是一种很有前途的治疗方法，伤口愈合快，并发症少，在皮肤伤口修复中具有广泛的临床应用潜力。
BackgroundThe lower third of the nose is one of the most important cosmetic units of the face, and its reconstructive techniques remain a big challenge. As an alternative approach to repair or regenerate the nasal tissue, the biomaterial-based strategy has been extensively investigated. The aim of this study is to determine the safety and efficacy of human acellular amniotic membrane (HAAM) to repair the full-thickness defects in the lower third of the nose in humans.MethodsIn this study, 180 patients who underwent excision of skin lesions of the lower third of the nose from 2012 to 2016 were included; of the patients, 92 received HAAM and Vaseline gauze treatments, and the other 88 patients received Vaseline gauze treatment only. The haemostasis time and the duration of operation were recorded during surgery; after surgery, the time to pain disappearance, scab formation and wound healing, and the wound healing rate were measured.ResultsImmediately after the HAAM implantation, a reduction of the haemostasis time and an accelerated disappearance of pain were observed. Compared with the control group, the formation and detachment of scab in patients who received the HAAM implantation were notably accelerated, postoperatively. When the diameter of the lesion exceeded 5 mm, the HAAM implantation was found to enhance the wound healing, although this enhancement was not seen when the diameter was less than 5 mm. Additionally, the HAAM implantation significantly reduced bleeding, wound infection and scar formation, postoperatively.ConclusionsHAAM-assisted healing is a promising therapy for lower third nasal reconstruction leading to rapid wound healing and fewer complications and thus has considerable potential for extensive clinical application in repairing skin wounds.