Incubation environment affects immune system development in a turtle with environmental sex determination
Incubation environment affects immune system development in a turtle with environmental sex determination
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DOI：
10.1670/07-133.1
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发表时间：
2008-09-01
影响因子：
0.8
通讯作者：
Nelson, Craig E.
中科院分区：
文献类型：
--
作者：
Freedberg, Steven;Greives, Timothy J.;Nelson, Craig E.
卵生动物的发育环境对孵化后表型有持续的影响。先天免疫反应是脊椎动物适应性的重要组成部分，因为它提供了对感染的普遍防御。此外，由于雄性脊椎动物感染的风险高于雌性，因此雄性可能比雌性更能从先天免疫力的增强中获益。我们确定了孵化温度对幼龟地图龟（Graptemys）的先天免疫反应的影响，通过在一定范围内的雄性和雌性生产温度下孵化卵，并评估由此产生的幼龟的血浆补体活性。我们发现了一个显着的孵化环境对循环补体在孵化Graptemys ouachitensis，与男性生产的温度产生最高的先天免疫反应。最重要的是，这些结果表明，在具有环境性别决定的物种中，免疫反应受到发育环境的影响，可能导致抵御病原体能力的性别差异。
The developmental environment can have lasting effects on posthatching phenotype in oviparous animals. Innate immune response is one important component of fitness in vertebrates because it provides a generalized defense against infection. In addition, because male vertebrates are at a higher risk of infection than females, males may benefit more from increased innate immunity than females. We determined the effects of incubation temperature on the innate immune response of hatchling map turtles (Graptemys) by incubating eggs at a range of male and female producing-temperatures and assessing plasma complement activity in the resulting hatchlings. We found a significant effect of incubation environment on circulating complement in hatchling Graptemys ouachitensis, with male-producing temperatures yielding the highest innate immune response. Most important, these results demonstrate that immune response is affected by developmental environment in a species with environmental sex determination, potentially resulting in sex differences in the ability to fend off pathogens.