Lung Interstitial Macrophages: Past, Present, and Future.
Lung Interstitial Macrophages: Past, Present, and Future.
复制标题
DOI：
10.1155/2018/5160794
复制
发表时间：
2018
影响因子：
4.1
通讯作者：
Marichal T
中科院分区：
文献类型：
--
作者：
Schyns J;Bureau F;Marichal T
长期以来，关于肺骨髓室的研究主要限于位于气道内的巨噬细胞，即众所周知的专门回收表面活性剂分子和清除碎片的肺泡巨噬细胞。然而，越来越多的报道强调了肺髓样区室的复杂性，其还包括树突状细胞、组织单核细胞和非肺泡巨噬细胞的不同亚群，称为间质巨噬细胞（IM）。最近的证据支持，在小鼠中，IM执行重要的免疫功能，包括维持肺稳态和预防免疫介导的过敏性气道炎症。在这篇文章中，我们描述了肺IM从历史的角度来看，我们审查目前的知识，其特点，个体发育和功能，主要是在啮齿动物。最后，我们强调该领域未来的一些重要挑战。
For a long time, investigations about the lung myeloid compartment have been mainly limited to the macrophages located within the airways, that is, the well-known alveolar macrophages specialized in recycling of surfactant molecules and removal of debris. However, a growing number of reports have highlighted the complexity of the lung myeloid compartment, which also encompass different subsets of dendritic cells, tissue monocytes, and nonalveolar macrophages, called interstitial macrophages (IM). Recent evidence supports that, in mice, IM perform important immune functions, including the maintenance of lung homeostasis and prevention of immune-mediated allergic airway inflammation. In this article, we describe lung IM from a historical perspective and we review current knowledge on their characteristics, ontogeny, and functions, mostly in rodents. Finally, we emphasize some important future challenges for the field.