Subthalamic Nucleus Neurons Differentially Encode Early and Late Aspects of Speech Production
Subthalamic Nucleus Neurons Differentially Encode Early and Late Aspects of Speech Production
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DOI：
10.1523/jneurosci.3480-17.2018
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发表时间：
2018-06-13
影响因子：
5.3
通讯作者：
Richardson, R. Mark
中科院分区：
文献类型：
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作者：
Lipski, Witold J.;Alhourani, Ahmad;Richardson, R. Mark
基底节-丘脑皮质环调节所有的运动行为，但关于基底节核团在言语产生中的作用，人们知之甚少。在帕金森氏病患者的脑深部刺激手术中，我们使用了颅内记录，检验了丘脑底核神经元的放电频率与言语的运动执行方面同步调制的假设。在12名受试者(男性和女性)的音节阅读任务中，79个单元的录音中有近一半表现出放电频率的调制。对丘脑下丘脑神经元活动相对于线索开始和产生开始的时间变化的试验计时显示，锁定线索呈现更多地与单位降低放电率相关，而锁定语言开始更多地与单位增加放电率相关。这些独特的数据表明，在语音产生过程中，丘脑的活动是动态的，反映了对不同群体的丘脑神经元的时间依赖性抑制和兴奋。
Basal ganglia-thalamocortical loops mediate all motor behavior, yet little detail is known about the role of basal ganglia nuclei in speech production. Using intracranial recording during deep brain stimulation surgery in humans with Parkinson's disease, we tested the hypothesis that the firing rate of subthalamic nucleus neurons is modulated in sync with motor execution aspects of speech. Nearly half of 79 unit recordings exhibited firing-rate modulation during a syllable reading task across 12 subjects (male and female). Trial-to-trial timing of changes in subthalamic neuronal activity, relative to cue onset versus production onset, revealed that locking to cue presentation was associated more with units that decreased firing rate, whereas locking to speech onset was associated more with units that increased firing rate. These unique data indicate that subthalamic activity is dynamic during the production of speech, reflecting temporally-dependent inhibition and excitation of separate populations of subthalamic neurons.