Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities
Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities
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DOI：
10.1111/j.1365-2869.2007.00561.x
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发表时间：
2007-03-01
影响因子：
4.4
通讯作者：
Archer, Simon N.
中科院分区：
文献类型：
--
作者：
Jones, Kay H. S.;Ellis, Jason;Archer, Simon N.
本研究的目的是调查年龄对睡眠和清醒活动的首选时间与时钟基因 PER3 中编码区可变数目串联重复 (VNTR) 多态性之间关联的影响。我们之前曾报道过这种多态性与昼夜偏好和睡眠时相延迟综合征（DSPS）有关。参与者（n = 1590；707 名男性和 883 名女性）完成了关于昼夜偏好的 Horne-Ostberg (HO) 问卷，并提供了 DNA 样本。总体 HO 分数根据年龄绘制。选择 5% 的极端值和中间值进行基因分型。在不同的年龄组（18-29、30-39、40-49 和 50 岁以上）中检查了 PER3 4 和 5 重复等位基因的频率。 4 次重复等位基因在夜间类型中显着更频繁，而 5 次重复等位基因在早晨类型中更频繁（Fisher 精确检验，P = 0.016）。对四个年龄组的分析表明，这种关联的强度随着年龄的增长而减弱，并且仅在最年轻的组（18-29 岁）中显着。这些结果扩展了我们之前关于 PER3 VNTR 与昼夜偏好之间关联的发现。他们还证明，与其他年龄组相比，年轻人的昼夜偏好与这种多态性的相关性更为密切。
The objective of this study was to investigate the effect of age on the association between preferred timing of sleep and waking activities and a coding-region variable number tandem repeat (VNTR) polymorphism in the clock gene PER3. We have previously reported this polymorphism to associate with diurnal preference and delayed sleep phase syndrome (DSPS). Participants (n = 1590; 707 males and 883 females) completed the Horne-Ostberg (HO) questionnaire for diurnal preference and provided a DNA sample. Overall HO scores were plotted against age. The 5% extremes and intermediates were selected for genotyping. Frequencies of the PER3 4- and 5-repeat alleles were examined in separate age groups (18-29, 30-39, 40-49 and 50+ years of age). The 4-repeat allele was significantly more frequent in evening types, and the 5-repeat allele more frequent in morning types (Fisher's exact test, P = 0.016). Analysis in the four age groupings revealed that the strength of this association attenuated with age and was significant only in the youngest group (18-29 years). These results extend our previous finding of an association between the PER3 VNTR and diurnal preference. They also demonstrate that diurnal preference in young people is more closely associated with this polymorphism than it is in other age groups.