Quantitative changes in regional cerebral blood flow induced by cold, heat and ischemic pain: a continuous arterial spin labeling study.
Quantitative changes in regional cerebral blood flow induced by cold, heat and ischemic pain: a continuous arterial spin labeling study.
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DOI：
10.1097/aln.0b013e31826a8a13
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发表时间：
2012-10
期刊：
影响因子：
8.8
通讯作者：
Deutsch G
中科院分区：
文献类型：
--
作者：
Frölich MA;Deshpande H;Ness T;Deutsch G
动脉自旋标记方法的发展，允许定量测量局部脑血流量（rCBF），并显示与任何状态相关的脑活动模式，如持续疼痛状态或因亲神经药物引起的变化。我们使用连续动脉自旋标记研究了10名健康受试者在静息基线、热、冷和缺血性疼痛期间在3T扫描仪上的三种疼痛条件的差异效应。冷痛显示左前扣带回皮质、左杏仁核、左角回和Brodmann 6区的绝对rCBF增加最大，小脑的rCBF显著降低。rCBF的变化是疼痛状态类型的特征：冷痛和热痛显示增加，而缺血状态显示与休息相比平均绝对灰质流量减少。受试者的疼痛耐受性和脑血流量之间存在相关性。定量rCBF变化是疼痛任务的特征，并且在Brodman 6区（负责整合对疼痛的运动反应的区域）存在一致的rCBF变化，这一观察结果应在寻求开发疼痛的成像生物标志物时提供非常有用的信息。可以想象，BA6的反应可以作为镇痛疗效的客观指标。
The development of arterial spin labeling methods, has allowed measuring regional cerebral blood flow (rCBF) quantitatively and to show the pattern of cerebral activity associated with any state such as a sustained pain state or changes due to a neurotropic drug. We studied the differential effects of three pain conditions in ten healthy subjects on a 3T scanner during resting baseline, heat, cold and ischemic pain using continuous arterial spin labeling. Cold pain showed the greatest absolute rCBF increases in left anterior cingulate cortex, left amygdala, left angular gyrus, and Brodmann Area 6, and a significant rCBF decrease in the cerebellum. Changes in rCBF were characteristic of the type of pain condition: cold and heat pain showed increases, while the ischemic condition showed a reduction in mean absolute gray matter flow compared to rest. An association of subjects’ pain tolerance and cerebral blood flow was noted. The observation that quantitative rCBF changes are characteristic of the pain task employed and that there is a consistent rCBF change in Brodman area 6, an area responsible for the integration of a motor response to pain, should provide extremely useful information in the quest to develop an imaging biomarker of pain. Conceivably, response in BA6 may serve as an objective measure of analgesic efficacy.