Hantavirus Transmission in Sylvan and Peridomestic Environments
Hantavirus Transmission in Sylvan and Peridomestic Environments
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DOI：
10.1007/s11538-009-9460-4
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发表时间：
2010-04-01
影响因子：
3.5
通讯作者：
Kuenzi, Amy
中科院分区：
文献类型：
--
作者：
Gedeon, Tomas;Bodelon, Clara;Kuenzi, Amy
我们建立了鹿鼠（Peromyscus maniculatus）汉坦病毒感染的室室模型，目的是比较在森林和周围环境中直接和间接传播的相对重要性。当受感染的老鼠和未受感染的老鼠接触时，就会发生直接传播，而当未受感染的老鼠与受感染的土壤接触时，就会发生间接传播。基于种群动态数据和对两种环境中汉坦病毒衰变的估计，我们的模型预测直接传播在森林环境中占主导地位，而两种途径在室内环境中都很重要。该模型允许我们计算一个基本的繁殖数R(0)，它表明病毒是地方性的还是从小鼠种群中被根除，在自治和时间周期模型中都是如此。我们的分析可用于评估各种根除策略。
We developed a compartmental model for hantavirus infection in deer mice (Peromyscus maniculatus) with the goal of comparing relative importance of direct and indirect transmission in sylvan and peridomestic environments. A direct transmission occurs when the infection is mediated by the contact of an infected and an uninfected mouse, while an indirect transmission occurs when the infection is mediated by the contact of an uninfected mouse with, for instance, infected soil. Based on population dynamics data and estimates of hantavirus decay in the two types of environments, our model predicts that direct transmission dominates in the sylvan environment, while both pathways are important in peridomestic environments. The model allows us to compute a basic reproduction number R (0), which indicates whether the virus will be endemic or eradicated from the mouse population, in both an autonomous and a time-periodic model. Our analysis can be used to evaluate various eradication strategies.