UNC-52/perlecan isoform diversity and function in Caenorhabditis elegans.
UNC-52/perlecan isoform diversity and function in Caenorhabditis elegans.
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DOI：
10.1042/bst0290171
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发表时间：
2001-05
影响因子：
3.9
通讯作者：
T. Rogalski;Gregory P. Mullen;Jason A. Bush;E. Gilchrist;D. Moerman
中科院分区：
文献类型：
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作者：
T. Rogalski;Gregory P. Mullen;Jason A. Bush;E. Gilchrist;D. Moerman
unc-52基因编码哺乳动物串珠素的线虫同源物，串珠素是细胞外基质的主要硫酸乙酰肝素蛋白聚糖。这是一种大的复杂蛋白质，其区域类似于低密度脂蛋白受体、层粘连蛋白和神经细胞粘附分子。通过选择性剪接产生三种主要类型的β-52/串珠素同种型，并且这些不同的蛋白质在整个发育过程中表现出复杂的空间和时间表达模式。unc-52基因在胚胎发育过程中对体壁肌的肌丝组装起重要作用。
The unc-52 gene encodes the nematode homologue of mammalian perlecan, the major heparan sulphate proteoglycan of the extracellular matrix. This is a large complex protein with regions similar to low-density lipoprotein receptors, laminin and neural cell-adhesion molecules. Three major classes of UNC-52/perlecan isoforms are produced through alternative splicing, and these distinct proteins exhibit complex spatial and temporal expression patterns throughout development. The unc-52 gene plays an essential role in myofilament assembly in body-wall muscle during embryonic development.