The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin
The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin
复制标题
肽对肾上腺髓质的作用。
DOI：
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
G. P. Lewis
中科院分区：
文献类型：
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作者：
W. Feldberg;G. P. Lewis
目前的实验表明，缓激素和血管紧张素是有效的髓质激素的释放，可能主要是肾上腺素，从肾上腺。在这方面，血管紧张素比任何其他已知物质都更有效。这些发现是在分析缓激肽对猫的动脉血压的抑制作用时偶然观察到的结果。为了使实验更加灵敏，我们切除腹部脏器，并通过腹腔动脉的中心残端从肾上上方的腹主动脉处注射缓激肽，缓激肽引起动脉血压下降，20-30秒后明显升高，动脉血压与心率加速相关。加压作用和加速作用在肾上腺切除后消失，因此是由于髓质激素的释放。缓激肽的这种作用在家兔和大鼠中已有报道（Lecomte, Troquet & Dresse, 1961），但没有关于释放的定量数据报道。因此，我们定量地研究了缓激肽和相关激肽的肾上腺素释放作用。将实验扩展到血管紧张素，显示出肾上髓质对这种肽的极端敏感性。另外三种肽，抗利尿激素，催产素和P物质，没有这种特性。在类似的条件下检查，它们没有引起肾上腺素从肾上释放出来。
The present experiments show that bradykinin and angiotensin are potent releasers of the medullary hormones, probably mainly adrenaline, from the suprarenal glands. Angiotensin is more potent in this respect than any other known substance. These findings were the outcome of a chance observation made when assaying bradykinin by its depressor action on the arterial blood pressure of the cat. On trying to render the assay more sensitive by removing the abdominal viscera and injecting the bradykinin through the central stump of the coeliac artery at its origin from the abdominal aorta above the suprarenals, bradykinin caused a fall, followed after 20-30 sec by a pronounced rise, in arterial blood pressure associated with acceleration of heart rate. The pressor effect and the cardio-acceleration were abolished after removal of the suprarenal glands and were therefore due to release of their medullary hormones. Such an action of bradykinin has been described in rabbits and rats (Lecomte, Troquet & Dresse, 1961), but no quantitative data of the release have been reported. We therefore investigated quantitatively this adrenaline-releasing effect of bradykinin and related kinins. On extending the experiments to angiotensin an extreme sensitivity of the suprarenal medulla to this peptide was revealed. Three other peptides, vasopressin, oxytocin and substance P, did not have this property. Examined under similar conditions they did not cause a detectable release of adrenaline from the suprarenals.