Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study
Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study
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DOI：
10.1097/00001756-200107200-00041
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发表时间：
2001-07-20
期刊：
影响因子：
1.7
通讯作者：
Skare, S
中科院分区：
文献类型：
--
作者：
Agartz, I;Andersson, JLR;Skare, S
采用弥散张量成像技术，对20例精神分裂症患者和24例健康人的脑容积进行了各向异性分数和平均弥散系数的测量。此外，3D SPGR用于将脑组织分割成灰色和白色物质以及脑脊液。在精神分裂症患者中，胼胝体压部和相邻枕部白色物质的各向异性分数降低。分割显示在各向异性分数减少的体积中没有组织缺陷。精神分裂症患者的总白色和灰质体积的平均弥散比健康人增加。这一发现支持了慢性精神分裂症中出现整体和区域性白色物质异常的观点。NeuroReport 12：2251-2254（C）2001 Lippincott威廉姆斯和威尔金斯。
Fractional anisotropy and the mean diffusion coefficient were measured in the cerebral volume in 20 schizophrenic and 24 healthy subjects, men and women, using diffusion tensor imaging. In addition, 3D SPGR was used for segmentation of brain tissue into grey and white matter and cerebrospinal fluid. In schizophrenic patients, fractional anisotropy was reduced in the splenium of the corpus callosum and in adjacent occipital white matter. The segmentation revealed no tissue deficits in the volume of reduced fractional anisotropy. The mean diffusion was increased in the total white and grey matter volume of the schizophrenic patients compared with the healthy subjects. The findings support the view that global and regional white matter abnormalities occur in chronic schizophrenia. NeuroReport 12:2251-2254 (C) 2001 Lippincott Williams & Wilkins.