Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium
Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium
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DOI：
10.1097/wnr.0b013e3282f48108
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发表时间：
2008-01-22
期刊：
影响因子：
1.7
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Foland, Lara C.;Altshuler, Lori L.;Thompson, Paul M.
先前的双相情感障碍的结构神经影像学研究报道了边缘系统结构的相互矛盾的结果。患者样本的药物异质性可能导致了这些不一致。使用结构磁共振成像，我们评估了锂治疗是否与双相成人样本中杏仁核和海马体积的差异相关。共收集了49例目前接受或未接受锂治疗的患者的磁共振成像扫描。杏仁核和海马体积进行了分析，使用基于张量的形态测量。变形图的组间统计学比较显示，与未服用锂的患者相比，接受锂治疗的患者表现出杏仁核和海马体的体积显著增加。我们的研究结果可能有助于解释以前双相情感障碍文献中的不一致之处。
Previous structural neuroimaging studies of bipolar disorder have reported conflicting findings in limbic structures. Medication heterogeneity of patient samples may have contributed to these inconsistencies. Using structural magnetic resonance imaging we assessed whether lithium treatment was associated with differences in amygdala and hippocampal volumes in a sample of bipolar adults. A total of 49 magnetic resonance imaging scans were collected from patients who were currently treated with or without lithium. Amygdala and hippocampal volumes were analyzed using tensor-based morphometry. Statistical between-group comparisons of deformation maps showed that patients treated with lithium exhibited significantly increased volumes of the amygdala and hippocampus compared with patients who were not taking lithium. Our findings may help to explain previous inconsistencies in the bipolar literature.