Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis.
Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis.
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DOI：
10.1016/s2468-1253(17)30004-3
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Ahuja V
中科院分区：
文献类型：
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作者：
Bopanna S;Ananthakrishnan AN;Kedia S;Yajnik V;Ahuja V
众所周知，溃疡性结肠炎会增加结直肠癌的风险。亚洲人群患散发性结直肠癌的风险被认为较低，并且亚洲地区与溃疡性结肠炎相关的结直肠癌的风险估计各不相同。这项荟萃分析从亚洲角度探讨了与溃疡性结肠炎相关的结直肠癌风险。我们在 PubMed 和 Embase 上搜索了从开始到 2016 年 7 月 1 日期间与溃疡性结肠炎中结直肠癌相关的术语。已发表文章的搜索是按国家对亚洲所有国家/地区进行的。我们纳入了有关不同时间点结直肠癌患病率和累积风险信息的研究。进行随机效应荟萃分析来计算汇总患病率以及 10 年、20 年和 30 年疾病的累积风险。我们的搜索找到了 2575 篇文章；其中 44 家符合纳入资格。我们的分析总共包括 31 287 名溃疡性结肠炎患者，其中总共报告了 293 名结直肠癌患者。使用各种研究的汇总患病率估计值，总体患病率为 0·85% (95% CI 0·65–1·04)。 10 年结直肠癌的风险为 0·02% (95% CI 0·00–0·04)，20 年为 4·81% (3·26–6·36)，30 年为 13·91% (7·09–20·72)。根据研究区域或时期对研究进行分层的亚组分析没有显示任何显着差异。我们发现亚洲溃疡性结肠炎患者患结直肠癌的风险与欧洲和北美最近的估计相似。因此，坚持筛查是必要的。为了更好地估计风险，需要进行更大规模的基于人群的前瞻性研究。
The increased risk of colorectal cancer in ulcerative colitis is well known. The risk of sporadic colorectal cancer in Asian populations is considered low and risk estimates of colorectal cancer related to ulcerative colitis from Asia vary. This meta-analysis is an Asian perspective on the risk of colorectal cancer related to ulcerative colitis. We searched PubMed and Embase for terms related to colorectal cancer in ulcerative colitis from inception to July 1, 2016. The search for published articles was done by country for all countries in Asia. We included studies with information on the prevalence and cumulative risk of colorectal cancer at various timepoints. A random-effects meta-analysis was done to calculate the pooled prevalence as well as a cumulative risk at 10 years, 20 years, and 30 years of disease. Our search identified 2575 articles; of which 44 were eligible for inclusion. Our analysis included a total of 31 287 patients with ulcerative colitis with a total of 293 reported colorectal cancers. Using pooled prevalence estimates from various studies, the overall prevalence was 0·85% (95% CI 0·65–1·04). The risks for colorectal cancer were 0·02% (95% CI 0·00–0·04) at 10 years, 4·81% (3·26–6·36) at 20 years, and 13·91% (7·09–20·72) at 30 years. Subgroup analysis by stratifying the studies according to region or period of the study did not reveal any significant differences. We found the risk of colorectal cancer in Asian patients with ulcerative colitis was similar to recent estimates in Europe and North America. Adherence to screening is therefore necessary. Larger population-based, prospective studies are required for better estimates of the risk.