Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy
Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy
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DOI：
10.1016/j.ijrobp.2005.09.004
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发表时间：
2006-02-01
影响因子：
7
通讯作者：
Elleaume, H
中科院分区：
文献类型：
--
作者：
Adam, JF;Joubert, A;Elleaume, H
目的：重原子增强同步加速器立体定向放射治疗（SSR）是一种涉及高z元素在肿瘤中的选择性积累，然后由同步加速器源的x射线进行立体定向照射的治疗方法。本研究的目的是在F98啮齿动物胶质瘤模型中，通过同时注射含碘造影剂和一种短暂血脑屏障打开剂（甘露醇），确定碘增强SSR的疗效是否可以进一步提高。方法与材料：F98细胞脑内接种后第14天，用50 kev x射线照射大鼠，同时静脉注射或颈动脉注射高渗甘露醇加碘（每组9 ~ 15只，共117只）。结果：对于剂量
Purpose: Heavy-atom-enhanced synchrotron stereotactic radiotherapy (SSR) is a treatment that involves selective accumulation of high-Z elements in tumors followed by stereotactic irradiation with X-rays from a synchrotron source. The purpose of this study was to determine whether the efficacy of iodine-enhanced SSR could be further improved in the F98 rodent glioma model, by using a concomitant injection of an iodinated contrast agent and a transient blood-brain barrier opener (mannitol) during irradiation.Methods and Materials: Fourteen days after intracerebral inoculations of F98 cells, the rats were irradiated with 50-keV X-rays while receiving an infusion of hyperosmotic mannitol with iodine, either intravenously or via the carotid (9 to 15 rats per group, 117 rats total).Results: For doses