The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues.
The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues.
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DOI：
10.1002/mabi.201500078
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发表时间：
2015-09
影响因子：
4.6
通讯作者：
Kazuhiro Sato;Shingo Kobayashi;Miho Kusakari;S. Watahiki;Masahiko Oikawa;T. Hoshiba;Masaru Tanaka
中科院分区：
文献类型：
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作者：
Kazuhiro Sato;Shingo Kobayashi;Miho Kusakari;S. Watahiki;Masahiko Oikawa;T. Hoshiba;Masaru Tanaka
合成了六种聚（丙烯酸2-甲氧基乙酯）（PMEA）类似物，并利用差示扫描量热法（DSC）对水合聚合物中的水结构进行了表征。水合的PMEA类似物表现出不同量的中间水。对PMEA类似物进行血小板粘附和蛋白吸附的非致血栓性评价。PMEA类似物抑制血小板粘附。此外，通过增加中间水的量抑制蛋白质的吸附和变形。本研究表明，中间水的量可能在表达聚合物材料的血液相容性方面起关键作用。
Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.