NUMEROUS GLIAL FIBRILLARY TANGLES IN OLIGODENDROGLIA IN CASES OF SUBACUTE SCLEROSING PANENCEPHALITIS WITH NEUROFIBRILLARY TANGLES
NUMEROUS GLIAL FIBRILLARY TANGLES IN OLIGODENDROGLIA IN CASES OF SUBACUTE SCLEROSING PANENCEPHALITIS WITH NEUROFIBRILLARY TANGLES
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DOI：
10.1016/0304-3940(95)11713-7
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发表时间：
1995-07-14
影响因子：
2.5
通讯作者：
YAGISHITA, S
中科院分区：
文献类型：
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作者：
IKEDA, K;AKIYAMA, H;YAGISHITA, S
在亚急性硬化性全脑炎(SSPE)中，神经元和少突胶质细胞均优先感染。在2例SSPE合并神经原纤维缠结(NFT)的尸检中，在少突胶质细胞内发现大量嗜银和tau阳性的胶质原纤维缠结(GFT)。GFT与NFT具有共同的磷酸化tau表位，但泛素为阴性。在电子显微镜下，GFT由密集的不规则编织的小管束组成。因此，SSPE的GFT不同于NFT显示的规律性小管收缩，也不同于其他一些细胞骨架疾病的GFT，据报道，GFT由直管组成。
Both neurons and oligodendroglia are preferentially infected in subacute sclerosing panencephalitis (SSPE). Massive argyrophilic and tau-positive glial fibrillary tangles (GFT) were found in oligodendroglia in two autopsy cases of SSPE with neurofibrillary tangles (NFT). GFT shared common phosphorylated tau-epitopes with NFT, but were negative for ubiquitin. Electron microscopically, GFT consisted of compact bundles of irregularly woven tubules. Thus, GFT in SSPE differed from NFT showing regular constriction of tubules and from GFT in some other cytoskeletal disorders in which GFT reportedly consisted of straight tubules.