lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions.
lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions.
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DOI：
10.1016/0012-1606(88)90414-9
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发表时间：
1988-11
影响因子：
2.7
通讯作者：
Paul W. Sternberg;Horvitz Hr
中科院分区：
文献类型：
--
作者：
Paul W. Sternberg;Horvitz Hr
确定细胞分裂不对称所必需的基因将是理解姐妹细胞在发育命运上如何不同的重要的第一步。线虫线虫的lin-17基因是一个很好的候选基因，lin-17突变导致几个原始细胞产生两种不同类型的姐妹细胞，而不是产生相同类型的姐妹细胞。此外，lin-17突变导致姐妹细胞大小相等，发育命运相同，表明lin-17在细胞不对称分裂时或之前起作用。lin-17基因产物参与多种组织中的不对称细胞分裂，表明lin-17在亲本细胞中建立细胞不对称性的一般机制中起作用。
The identification of a gene necessary for the asymmetry of cell division would be an important first step toward understanding how sister cells come to differ in their developmental fates. Thelin-17gene of the nematodeCaenorhabditis elegansis an excellent candidate for being such a gene.lin-17mutations cause several blast cells that normally generate sister cells of two distinct types to generate instead sister cells of the same type. Moreover,lin-17mutations cause sister cells to be equal in size as well as equivalent in developmental fate, suggesting thatlin-17acts at or prior to the asymmetric cell division. Thelin-17gene product is involved in asymmetric cell divisions in a variety of tissues, indicating thatlin-17functions in a general mechanism for the establishment of cellular asymmetry in parent cells.