Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers
Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers
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DOI：
10.1177/0333102411431333
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发表时间：
2012-01-01
期刊：
影响因子：
4.9
通讯作者：
Ashina, Messoud
中科院分区：
文献类型：
--
作者：
Amin, Faisal Mohammad;Asghar, Mohammad Sohail;Ashina, Messoud
目的：为了探讨血管舒张与迟发性头痛之间的可能关系，我们采用高分辨率磁共振血管造影（MRA）检测了垂体腺苷酸环化酶激活多肽38（PACAP 38）对脑膜中动脉（MMA）和大脑中动脉（MCA）的影响。在一项双盲、随机、安慰剂对照研究中，14名健康志愿者在输注（20分钟）10 pmol/kg/min PACAP 38或安慰剂后重复扫描。此外，四名参与者进行扫描皮下注射舒马曲坦（6毫克）。结果：我们发现显着扩张的MMA（p = 0.00001），但不是MCA（p = 0.50）后PACAP 38。安慰剂治疗后无变化（p > 0.40）。血管舒张（范围16-23%）持续5小时以上。舒马曲坦选择性收缩MMA达12.3%（p = 0.043）。结论：PACAP 38引起的头痛与MMA的延长扩张有关，但与MCA无关。舒马曲坦缓解头痛的同时收缩MMA，但不收缩MCA。
Aim: To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on the middle meningeal artery (MMA) and middle cerebral artery (MCA) using high resolution magnetic resonance angiography (MRA).Methods: In a double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) of 10 pmol/kg/min PACAP38 or placebo. In addition, four participants were scanned following subcutaneous sumatriptan (6 mg).Results: We found significant dilatation of the MMA (p = 0.00001), but not of the MCA (p = 0.50) after PACAP38. There was no change after placebo (p > 0.40). Vasodilatation (range 16-23%) lasted more than 5 h. Sumatriptan selectively contracted the MMA by 12.3% (p = 0.043).Conclusion: PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.