Impact of 13-Valent Pneumococcal Conjugate Vaccination in Invasive Pneumococcal Disease Incidence and Mortality
Impact of 13-Valent Pneumococcal Conjugate Vaccination in Invasive Pneumococcal Disease Incidence and Mortality
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DOI：
10.1093/cid/ciu524
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发表时间：
2014-10-15
影响因子：
11.8
通讯作者：
Valentiner-Branth, Palle
中科院分区：
文献类型：
--
作者：
Harboe, Zitta Barrella;Dalby, Tine;Valentiner-Branth, Palle
背景13价肺炎球菌结合疫苗（PCV 13）在人群水平的影响尚不清楚。我们探讨了PCV 13在降低侵袭性肺炎球菌病（IPD）相关发病率和死亡率方面的作用，以及特定类型的变化是否可归因于疫苗接种或预期作为自然周期性变化的一部分。这是一项基于实验室监测数据和丹麦民事登记系统的丹麦全国人群队列研究。估计了基线（2000-2007年）、7价肺炎球菌结合疫苗（PCV 7）（2008-2010年）和PCV 13（2011-2013年）期间IPD发病率和死亡率的变化。预测的血清型的发病率估计控制的周期性趋势，从历史模式中观察到在过去的20年。我们观察到，在引入PCV 13后，总人群中IPD发病率降低了21%（95%置信区间[CI]，17%-25%），
Background. The impact of the 13-valent pneumococcal conjugate vaccine (PCV13) at the population level is unclear. We explored PCV13's effect in reducing invasive pneumococcal disease (IPD)-related morbidity and mortality, and whether serotype-specific changes were attributable to vaccination or expected as a part of natural, cyclical variations.Methods. This was a Danish nationwide population-based cohort study based on the linkage of laboratory surveillance data and the Danish Civil Registration System. Changes in IPD incidence and mortality during baseline (2000-2007), 7-valent pneumococcal conjugate vaccine (PCV7) (2008-2010), and PCV13 (2011-2013) periods were estimated. Predicted incidences of serotypes were estimated controlling for cyclical trends from historical patterns observed during the past 20 years.Results. We observed a 21% reduction (95% confidence interval [CI], 17%-25%) in IPD incidence in the total population after PCV13's introduction, and a 71% reduction (95% CI, 62%-79%) in children aged