New Insights from Drosophila into the Regulation of EGFR Signaling
New Insights from Drosophila into the Regulation of EGFR Signaling
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DOI：
10.1007/978-1-4939-7219-7_2
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发表时间：
2017-01-01
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影响因子：
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通讯作者：
Harden, Nicholas
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文献类型：
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作者：
Harden, Nicholas
对果蝇EGFR信号的遗传分析有着长期的记录，为我们理解EGFR途径做出了重要贡献。虽然中央RAS/MAPK通路早已被很好地定义，但关于它与其他通路的相互作用以及它是如何被调控的，还有很多需要学习。对于错误调控的EGFR信号在肿瘤发生中的作用，更好地理解EGFR信号的调控是特别有意义的。最近的研究得出了一些令人惊讶的结果，确定了EGFR以意想不到的方式发挥作用的调节者。
Genetic analysis of Egfr signaling in Drosophila has a long-standing track record of making important contributions to our understanding of the Egfr pathway. While the central Ras/MAPK pathway has long been well defined, there is much to learn with regard to its cross talk with other pathways and how it is regulated. A better understanding of the regulation of Egfr signaling is of particular interest with regard to the participation of misregulated Egfr signaling in tumorigenesis. Recent studies in the fly have led to some surprising results, identifying regulators of Egfr acting in unexpected ways.