[The effect of zinc depletion on the fat content and fatty acid composition of the liver and brain in forcibly fed rats].
[The effect of zinc depletion on the fat content and fatty acid composition of the liver and brain in forcibly fed rats].
复制标题
缺锌对强行喂养大鼠肝脏和大脑脂肪含量及脂肪酸组成的影响
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
M. Kirchgessner
中科院分区：
文献类型：
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作者：
K. Eder;M. Kirchgessner
在本研究中，研究了锌缺乏对高食物摄入大鼠肝脏脂肪含量和脂肪酸组成以及大脑脂肪酸组成的影响。使用强制喂养技术，在第 1 天至第 4 天每天给大鼠喂食 14.5 克食物，随后几天喂食 11.6 克食物。 7天后，缺锌动物出现脂肪肝，其特征是脂肪含量（68%）和干物质（23%）增加。缺锌动物肝脏中月桂酸、肉豆蔻酸、肉豆蔻脑酸、棕榈酸、棕榈油酸和油酸的含量也增加了100%至200%，而花生四烯酸的含量则减少了29%。缺锌不会改变肝脏中磷脂酰胆碱和磷脂酰乙醇胺的含量，但这些磷脂的脂肪酸组成发生了变化。缺锌动物的肝脏磷脂中花生四烯酸的比例减少，但二十二碳六烯酸的比例增加。在缺锌动物中，肝脏中的脂肪含量与肝脏中亚油酸和花生四烯酸的比例也存在正相关关系，而肝脏中的脂肪含量与肝脏中花生四烯酸的量之间也存在负相关关系。这些相关性以及缺锌动物肝脏脂肪酸组成的变化表明，脂肪肝可能是亚油酸代谢紊乱的结果。相比之下，缺锌并不影响大脑的脂肪酸组成。这意味着大脑可以免受短期缺锌的影响。
In the present work the influence of zinc deficiency on fat content and fatty acid composition of liver and fatty acid composition of brain of rats with a high food intake was investigated. Using the force-feeding technique the rats were fed 14.5 g food daily at days 1 to 4, and then 11.6 g food for later days. After 7 days the zinc-deficient animals had a fatty liver which was characterized by an increase in fat content (68%) and dry matter (23%). The amounts of lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, and oleic acid were also increased by 100 to 200% in the liver of zinc-deficient animals, whereas the amount of arachidonic acid was decreased by 29%. The amounts of phosphatidylcholine and phosphatidylethanolamine in the liver were not changed by zinc deficiency, but the fatty acid composition of these phospholipids was changed. The liver phospholipids of zinc-deficient animals had a decreased proportion of arachidonic acid, but an increased proportion of docosahexaenoic acid. In the zinc-deficient animals there also existed a positive correlation between the fat content in the liver and the ratio between linoleic and arachidonic acid in the liver and a negative correlation between the fat content in the liver and the amount of arachidonic acid in the liver. These correlations as well as the changes in liver fatty acid composition of zinc-deficient animals suggest that the fatty liver might be the result of a disturbed metabolism of linoleic acid. In contrast, zinc deficiency did not influence the fatty acid composition of brain. This means that brain is protected against the effects of short-term zinc deficiency.